Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2883762 | 0.73 | MAPT (0.42) | KDM4EMAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL5236340 | 0.71 | ALDH1A1 (0.40) | KDM4EMAPTALDH1A1NPSR1BAZ2B | |
| SCHEMBL11617070 | 0.70 | ALDH1A1 (0.42) | KDM4EMAPTALDH1A1NPSR1TSHR | |
| SCHEMBL21822502 | 0.70 | MAPT (0.50) | KDM4EMAPTTDP1TSHRPOLB | |
| SCHEMBL2886428 | 0.69 | KMT2A (0.35) | KDM4EMAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL5514070 | 0.69 | CNR2 (0.42) | KDM4EMAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL1844676 | 0.66 | NPC1 (0.43) | MAPTL3MBTL1POLBNOD2NOD1 | |
| SCHEMBL4625675 | 0.66 | CYP4F2 (0.43) | TDP1ALDH1A1MAPK1L3MBTL1BAZ2B | |
| SCHEMBL9974823 | 0.64 | MAPT (0.53) | KDM4EMAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL8072052 | 0.64 | LMNA (0.56) | KDM4EMAPTTDP1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124489-A1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | Fibrogen, Inc. (US) | 2017-02-01 | — | — | EP | disclosed |
| EP-2016078-B1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2016-06-15 | — | — | EP | disclosed |