SCHEMBL8072052

SCHEMBL8072052

CCOC(=O)c1cc(Cl)nn1C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.56
SMN1; SMN2 Q16637 6/20 0.52
RAB9A P51151 4/20 0.52
NPC1 O15118 3/20 0.52
MAPT P10636 3/20 0.52
KDM4E B2RXH2 3/20 0.50
FAAH O00519 2/20 0.45
BAZ2B Q9UIF8 1/20 0.44
BAZ2A Q9UIF9 1/20 0.44
POLB P06746 2/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TDP1 Q9NUW8 2/20 0.42
MAPK1 P28482 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
PDE4B Q07343 1/20 0.42
ATM Q13315 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1894879 0.83 LMNA (0.52) LMNASMN1; SMN2RAB9ANPC1MAPT
SCHEMBL18007685 0.81 LMNA (0.49) LMNASMN1; SMN2RAB9ANPC1MAPT
SCHEMBL7698241 0.81 LMNA (0.61) LMNASMN1; SMN2RAB9ANPC1MAPT
SCHEMBL1850876 0.81 LMNA (0.51) LMNASMN1; SMN2RAB9ANPC1MAPT
SCHEMBL1915343 0.81 CA12 (0.42) LMNASMN1; SMN2RAB9ANPC1MAPT
SCHEMBL973113 0.80 LMNA (0.50) LMNASMN1; SMN2RAB9ANPC1MAPT
SCHEMBL20269905 0.80 LMNA (0.50) LMNASMN1; SMN2RAB9ANPC1MAPT
SCHEMBL26104183 0.80 RAB9A (0.54) LMNASMN1; SMN2RAB9ANPC1MAPT
SCHEMBL286585 0.80 LMNA (0.50) LMNASMN1; SMN2RAB9ANPC1MAPT
SCHEMBL20177039 0.80 LMNA (0.53) LMNASMN1; SMN2RAB9ANPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1020447-A1 PYRAZOLE COMPOUNDS AND PLANT DISEASE CONTROL AGENT Nissan Chemical Industries, Ltd. (JP) 2000-07-19 EP disclosed
EP-0757987-B1 Pyrazole-carboxylic acid derivatives as plant disease control agents NISSAN CHEMICAL IND LTD (JP) 2000-07-19 EP disclosed
US-5817829-A FUNGICIDES NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-06 US disclosed
EP-0757987-A1 PYRAZOLECARBOXYLIC ACID DERIVATIVE AND PLANT DISEASE CONTROL AGENT NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1997-02-12 EP disclosed