SCHEMBL1782232

SCHEMBL1782232

CCOc1cccc2onc(N)c12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 8/20 0.46
FLT3 P36888 6/20 0.46
KIT P10721 6/20 0.46
MAP4K4 O95819 2/20 0.46
PDGFRB P09619 2/20 0.46
PIM1 P11309 2/20 0.46
FGFR1 P11362 2/20 0.46
PDGFRA P16234 2/20 0.46
PRKACA P17612 2/20 0.46
LTK P29376 2/20 0.46
GRK5 P34947 2/20 0.46
CDK8 P49336 2/20 0.46
CDK7 P50613 2/20 0.46
CDK9 P50750 2/20 0.46
LIMK1 P53667 2/20 0.46
MAP2K1 Q02750 2/20 0.46
ACVR1 Q04771 2/20 0.46
MST1R Q04912 2/20 0.46
MAP4K2 Q12851 2/20 0.46
ROCK1 Q13464 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1781983 0.81 KDR (0.50) KDRFLT3KITMAP4K4PDGFRB
SCHEMBL10422418 0.81 KDR (0.44) KDRFLT3KITMAP4K4PDGFRB
SCHEMBL10422419 0.80 KDR (0.43) KDRFLT3KITMAP4K4PDGFRB
SCHEMBL21266923 0.80 SGMS2 (0.55) KDRFLT3KITMAP4K4PDGFRB
SCHEMBL5049132 0.80 KDR (0.43) KDRFLT3KITMAP4K4PDGFRB
SCHEMBL2440688 0.80 KDR (0.46) KDRFLT3KITMAP4K4PDGFRB
SCHEMBL10423066 0.79 KDR (0.44) KDRFLT3KITMAP4K4PDGFRB
SCHEMBL1784179 0.78 SGMS2 (0.46) KDM4EMEN1MAPTKMT2APABPC1
SCHEMBL29593002 0.78 KDR (0.44) KDRFLT3KITMAP4K4PDGFRB
SCHEMBL31432578 0.77 KDR (0.46) KDRFLT3KITMAP4K4PDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062393-A1 Compounds CTXT PTY LTD (AU) 2026-03-05 US disclosed
US-12365655-B2 Compounds CTXT PTY LTD (AU) 2025-07-22 US disclosed
CN-112334466-B Compounds of formula (I) CTXT私人有限公司 2025-05-30 CN disclosed
EP-4335439-A2 COMPOUNDS CTXT PTY LTD (AU) 2024-03-13 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
EP-3810602-A1 COMPOUNDS CTXT Pty Limited (AU) 2021-04-28 EP disclosed
CN-112334466-A Compound (I) CTXT私人有限公司 2021-02-05 CN disclosed
US-20110118240-A2 4-Amino-1,2,3-Benzoxathiazine-Derivatives as Pesticides BAYER CROPSCIENCE AG (DE) 2011-05-19 US disclosed
US-20110118240-A2 4-Amino-1,2,3-Benzoxathiazine-Derivatives as Pesticides BAYER CROPSCIENCE AG (DE) 2011-05-19 US disclosed
US-20110118240-A2 4-Amino-1,2,3-Benzoxathiazine-Derivatives as Pesticides BAYER CROPSCIENCE AG (DE) 2011-05-19 US disclosed
US-20100267703-A1 4-Amino-1,2,3-benzoxathiazine-Derivatives as Pesticides BAYER CROPSCIENCE AG (DE) 2010-10-21 US disclosed
US-20100267703-A1 4-Amino-1,2,3-benzoxathiazine-Derivatives as Pesticides BAYER CROPSCIENCE AG (DE) 2010-10-21 US disclosed
US-20100267703-A1 4-Amino-1,2,3-benzoxathiazine-Derivatives as Pesticides BAYER CROPSCIENCE AG (DE) 2010-10-21 US disclosed
WO-2010072310-A1 4-AMINO-1,2,3- BENZOXATHIAZINE DERIVATIVES AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-07-01 WO disclosed
WO-2010072310-A1 4-AMINO-1,2,3- BENZOXATHIAZINE DERIVATIVES AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-07-01 WO disclosed
EP-2196461-A1 4-Amino-1,2,3-benzoxathiazine-derivatives as pesticides Bayer CropScience AG (DE) 2010-06-16 EP disclosed
EP-2196461-A1 4-Amino-1,2,3-benzoxathiazine-derivatives as pesticides Bayer CropScience AG (DE) 2010-06-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 KDR 4509/4885FLT3 2102/4885KIT 520/4885
US-20100267703-A1 4-Amino-1,2,3-benzoxathiazine-Derivatives as Pesticides P2RX5, SLC1A5, P2RX4 KDR 3106/4885FLT3 1183/4885KIT 4036/4885
US-20110118240-A2 4-Amino-1,2,3-Benzoxathiazine-Derivatives as Pesticides P2RX5, P2RX4, SLC1A5 KDR 3014/4885FLT3 1080/4885KIT 3872/4885
US-20260062393-A1 Compounds SCN2B, ABCB11, SCN1B KDR 1022/4885FLT3 2336/4885KIT 2385/4885
US-12365655-B2 Compounds SLC10A1, ABCB11, PCSK9 KDR 4505/4885FLT3 2101/4885KIT 519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.