Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 10/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.45 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17825003 | 0.94 | PARG (0.56) | PARGTSHRALDH1A1HPGDHTT | |
| SCHEMBL17832096 | 0.83 | PARG (0.69) | PARG | |
| SCHEMBL17824737 | 0.81 | PARG (0.47) | PARGTSHR | |
| SCHEMBL19770730 | 0.73 | PARG (1.00) | PARG | |
| SCHEMBL4921799 | 0.69 | TAS2R8 (0.54) | TSHRALDH1A1HPGDHTTMAPT | |
| SCHEMBL13528242 | 0.69 | MAPT (0.78) | TSHRALDH1A1MAPTTP53MEN1 | |
| SCHEMBL6644454 | 0.68 | TSHR (0.48) | PARGTSHRALDH1A1HTTMEN1 | |
| SCHEMBL16674525 | 0.68 | TSHR (0.73) | TSHRALDH1A1HPGDMAPTTP53 | |
| SCHEMBL8244822 | 0.68 | EGLN1 (0.66) | TSHRALDH1A1HTTHSD17B10MEN1 | |
| SCHEMBL6664815 | 0.66 | TAS2R8 (0.44) | TSHRALDH1A1HTTHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230273-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | Cancer Research Technology Ltd (GB) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016092326-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-16 | — | — | WO | disclosed |