Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 10/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TAS2R8 | Q9NYW2 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17824735 | 0.81 | PARG (0.56) | PARGTSHR | |
| SCHEMBL17825003 | 0.77 | PARG (0.56) | PARGTSHR | |
| SCHEMBL17832096 | 0.76 | PARG (0.69) | PARG | |
| SCHEMBL4921799 | 0.65 | TAS2R8 (0.54) | TAS2R8TSHRLMNATDP1 | |
| SCHEMBL19770730 | 0.64 | PARG (1.00) | PARG | |
| SCHEMBL2204904 | 0.60 | TDP1 (0.65) | TAS2R8TSHRTDP1 | |
| SCHEMBL18256127 | 0.60 | ADORA2B (0.54) | TSHRLMNA | |
| SCHEMBL14831873 | 0.60 | GAA (0.63) | TSHRLMNA | |
| SCHEMBL6665457 | 0.60 | PDE4A (0.65) | — | |
| SCHEMBL6664815 | 0.60 | TAS2R8 (0.44) | TAS2R8TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230273-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | Cancer Research Technology Ltd (GB) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016092326-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-16 | — | — | WO | disclosed |