Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 10/20 | 0.39 |
| ▸ | EDNRA | P25101 | 10/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17825461 | 0.80 | KDM4E (0.57) | KDM4ECHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL24759681 | 0.73 | MTNR1A (0.42) | KDM4EHDAC4HDAC6MTNR1AMTNR1B | |
| SCHEMBL31692003 | 0.72 | NUDT1 (0.42) | MTNR1AMTNR1BPOLBTDP1CYP3A4 | |
| SCHEMBL2625477 | 0.72 | NUDT1 (0.42) | MTNR1AMTNR1BPOLBTDP1CYP3A4 | |
| Hydrogen Sulfide SCHEMBL28066375 | 0.72 | HDAC3 (0.59) | KDM4ECHRM2CHRM4CHRM5CHRM1 | |
| Hydrogen Sulfide SCHEMBL27894390 | 0.72 | HDAC3 (0.59) | KDM4ECHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9341831 | 0.71 | EDNRB (0.41) | EDNRBEDNRA | |
| SCHEMBL1888803 | 0.70 | KDM4E (0.46) | KDM4ECHRM2CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL27886095 | 0.70 | HDAC3 (0.57) | KDM4ECHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL73063 | 0.70 | HDAC3 (0.61) | KDM4ECHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230276-A1 | GLP-1 RECEPTOR MODULATORS | Celgene International II Sarl (CH) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016094729-A1 | GLP-1 RECEPTOR MODULATORS | CELGENE INTERNATIONAL II SARL (CH) | 2016-06-16 | — | — | WO | disclosed |