Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 16/20 | 0.75 |
| ▸ | SIRT1 | Q96EB6 | 16/20 | 0.75 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229454 | 0.89 | SIRT2 (0.78) | SIRT2SIRT1 | |
| SCHEMBL17826587 | 0.87 | ALDH1A1 (0.60) | SIRT2SIRT1SIRT3 | |
| SCHEMBL17826580 | 0.85 | SMN1; SMN2 (0.59) | SIRT2SIRT1 | |
| Hydrochloric Acid SCHEMBL1708340 | 0.85 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL17826579 | 0.84 | SIRT2 (0.63) | SIRT2SIRT1SIRT3 | |
| SCHEMBL17826584 | 0.82 | MEN1 (0.65) | SIRT2SIRT1SIRT3 | |
| SCHEMBL17826597 | 0.82 | SIRT2 (0.73) | SIRT2SIRT1SIRT3 | |
| SCHEMBL17826576 | 0.82 | POLB (0.64) | SIRT2SIRT1SIRT3 | |
| SCHEMBL17826598 | 0.82 | SIRT2 (0.77) | SIRT2SIRT1SIRT3 | |
| SCHEMBL17826596 | 0.81 | SIRT2 (0.78) | SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365508-B2 | Aroyl thiourea derivatives | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2016-06-14 | — | — | US | disclosed |