Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 16/20 | 0.78 |
| ▸ | SIRT1 | Q96EB6 | 15/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.63 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.63 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.63 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17826590 | 0.92 | SIRT2 (0.66) | SIRT2SIRT1POLBMAPTHTT | |
| SCHEMBL17826579 | 0.90 | SIRT2 (0.63) | SIRT2SIRT1MAPTSIRT3 | |
| Hydrochloric Acid SCHEMBL1707443 | 0.87 | SIRT2 (0.98) | SIRT2SIRT1SIRT3 | |
| SCHEMBL17826584 | 0.84 | MEN1 (0.65) | SIRT2SIRT1RAB9ASMN1; SMN2SIRT3 | |
| SCHEMBL17826597 | 0.84 | SIRT2 (0.73) | SIRT2SIRT1SIRT3 | |
| SCHEMBL17826595 | 0.83 | SIRT2 (0.76) | SIRT2SIRT1POLBMAPTTDP1 | |
| SCHEMBL17826582 | 0.83 | ALDH1A1 (0.64) | SIRT2SIRT1POLBMAPTHTT | |
| SCHEMBL16229387 | 0.82 | SIRT2 (0.67) | SIRT2SIRT1POLBMAPTHTT | |
| SCHEMBL17826575 | 0.81 | SIRT2 (0.75) | SIRT2SIRT1SIRT3 | |
| Hydrochloric Acid SCHEMBL3718814 | 0.81 | SIRT2 (0.62) | SIRT2SIRT1POLBMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365508-B2 | Aroyl thiourea derivatives | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2016-06-14 | — | — | US | disclosed |