Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229455 | 0.89 | SIRT2 (0.63) | SMN1; SMN2MAPTALDH1A1NPC1HPGD | |
| SCHEMBL17826582 | 0.87 | ALDH1A1 (0.64) | SMN1; SMN2MAPTALDH1A1NPC1HPGD | |
| SCHEMBL17826595 | 0.87 | SIRT2 (0.76) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL17826587 | 0.86 | ALDH1A1 (0.60) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL17826576 | 0.86 | POLB (0.64) | SMN1; SMN2ALDH1A1NPC1RAB9ASIRT2 | |
| SCHEMBL17826575 | 0.85 | SIRT2 (0.75) | SIRT2SIRT1 | |
| Hydrochloric Acid SCHEMBL1707574 | 0.85 | SIRT2 (0.78) | SIRT2SIRT1 | |
| SCHEMBL17826583 | 0.84 | ALDH1A1 (0.64) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL3059631 | 0.82 | ALDH1A1 (0.76) | SMN1; SMN2MAPTALDH1A1NPC1HPGD | |
| SCHEMBL17826579 | 0.81 | SIRT2 (0.63) | MAPTALDH1A1SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365508-B2 | Aroyl thiourea derivatives | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2016-06-14 | — | — | US | disclosed |