Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.76 |
| ▸ | SIRT1 | Q96EB6 | 9/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229456 | 0.90 | SIRT2 (0.80) | SIRT2SIRT1ALDH1A1GLAPOLB | |
| SCHEMBL17826580 | 0.87 | SMN1; SMN2 (0.59) | SIRT2SIRT1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL17826582 | 0.87 | ALDH1A1 (0.64) | SIRT2SIRT1ALDH1A1POLBMAPT | |
| SCHEMBL17826597 | 0.86 | SIRT2 (0.73) | SIRT2SIRT1EPHX1 | |
| SCHEMBL17826576 | 0.86 | POLB (0.64) | SIRT2SIRT1ALDH1A1POLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1706807 | 0.85 | SIRT2 (1.00) | SIRT2SIRT1 | |
| SCHEMBL17826583 | 0.84 | ALDH1A1 (0.64) | SIRT2SIRT1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL17826596 | 0.83 | SIRT2 (0.78) | SIRT2SIRT1POLBMAPTSMN1; SMN2 | |
| SCHEMBL17826590 | 0.83 | SIRT2 (0.66) | SIRT2SIRT1POLBMAPTTDP1 | |
| SCHEMBL17826575 | 0.81 | SIRT2 (0.75) | SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365508-B2 | Aroyl thiourea derivatives | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2016-06-14 | — | — | US | disclosed |