Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24046966 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL17184668 | 0.81 | NPC1 (0.39) | SMN1; SMN2NPC1RAB9AMAPTHTR2A | |
| SCHEMBL17826983 | 0.81 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9AMAPTHTR2A | |
| SCHEMBL17184615 | 0.81 | KEAP1 (0.40) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL17826990 | 0.80 | AHR (0.43) | MAPTLMNAALDH1A1NOTUMKDM4E | |
| SCHEMBL12963905 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AMAPTMEN1 | |
| SCHEMBL27738907 | 0.78 | MCHR1 (0.47) | SMN1; SMN2NPC1RAB9AMAPTHTR2A | |
| SCHEMBL17826982 | 0.78 | MAPT (0.56) | SMN1; SMN2NPC1RAB9AMAPTHTR2A | |
| SCHEMBL15262927 | 0.77 | LMNA (0.33) | SMN1; SMN2NPC1RAB9ACHRM1LMNA | |
| SCHEMBL17826984 | 0.76 | CYP1A2 (0.44) | CASP1CYP1A2PDE4DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379535-B1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2016-06-15 | — | — | EP | disclosed |