Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL4234179 | 0.94 | HRH4 (0.39) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL8887482 | 0.93 | HRH4 (0.34) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL5840054 | 0.93 | HRH4 (0.38) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL5321413 | 0.91 | LMNA (0.33) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL1680140 | 0.91 | LMNA (0.33) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL28543874 | 0.90 | HRH4 (0.39) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL28074178 | 0.90 | HRH1 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL1668636 | 0.90 | HRH4 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL7444650 | 0.90 | HRH4 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL289072 | 0.90 | HRH4 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005053768-A1 | BIOACTIVE ORGANIC COATINGS WHICH CAN BE APPLIED TO VASCULAR ENDOPROSTHESES | ALCHIMER (FR) | 2005-06-16 | — | — | WO | claimed |
| US-6730144-B2 | MODIFIED LYSING ENZYME IMMOBILIZED ON SURFACE OF A HEPA FILTER | NIKKI - UNIVERSAL CO., LTD. (JP) | 2004-05-04 | — | — | US | claimed |
| US-20040050254-A1 | AIR PURIFYING FILTER USING MODIFIED ENZYMES | NIKKI-UNIVERSAL CO., LTD. (JP) | 2004-03-18 | — | — | US | claimed |
| US-5641852-A | REACTING CYANATE RESIN AND COMPOUND CONTAINING AT LEAST ONE PHENOLIC HYDROXYL RADICAL TO FORM IMIDO CARBONATE | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1997-06-24 | — | — | US | claimed |
| EP-0281809-B1 | SUSTAINED RELEASE COMPOSITIONS FOR PARENTERAL ADMINISTRATION AND THEIR USE | AMERICAN CYANAMID COMPANY (US) | 1993-08-04 | — | — | EP | claimed |
| US-4857505-A | Sustained release compositions for parenteral administration and their use | AMERICAN CYANAMID COMPANY (US) | 1989-08-15 | — | — | US | claimed |
| EP-0281809-A2 | Sustained release compositions for parenteral administration and their use | AMERICAN CYANAMID COMPANY (US) | 1988-09-14 | — | — | EP | claimed |
| CN-117263746-A | Impact-resistant bio-based coating material capable of self-repairing at room temperature and preparation method thereof | 山东农业大学 | 2023-12-22 | — | — | CN | disclosed |
| CN-110951252-A | Novel cyanate/epoxy modified resin matrix composition | 同济大学 | 2020-04-03 | — | — | CN | disclosed |
| US-20110116972-A1 | MICROFLUIDIC ASSAYS AND MICROFLUIDIC DEVICES | GYROS PATENT AB (SE) | 2011-05-19 | — | — | US | disclosed |
| EP-2237037-A1 | Microfluidic device and use thereof | GYROS PATENT AB (SE) | 2010-10-06 | — | — | EP | disclosed |
| EP-2032984-A1 | MICROFLUIDIC ASSAYS AND MICROFLUIDIC DEVICES | GYROS PATENT AB (SE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007069940-A1 | MICROFLUIDIC ASSAYS AND MICROFLUIDIC DEVICES | GYROS PATENT AB (SE) | 2007-06-21 | — | — | WO | disclosed |
| EP-0281809-B1 | SUSTAINED RELEASE COMPOSITIONS FOR PARENTERAL ADMINISTRATION AND THEIR USE | AMERICAN CYANAMID COMPANY (US) | 1993-08-04 | — | — | EP | disclosed |
| EP-0328256-A1 | Glass fibers coated with agarose for use as column packing or chromatographic media for bioseparations | OWENS-CORNING FIBERGLAS CORPORATION (US) | 1989-08-16 | — | — | EP | disclosed |
| US-4857505-A | Sustained release compositions for parenteral administration and their use | AMERICAN CYANAMID COMPANY (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0281809-A2 | Sustained release compositions for parenteral administration and their use | AMERICAN CYANAMID COMPANY (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4650755-A | IMMOBILIZED ENZYMES | PURIFICATION ENGINEERING, INC. (US) | 1987-03-17 | — | — | US | disclosed |
| US-4341707-A | CHEMICAL INTERMEDIATES; PEPTIDE SYNTHESIS | Ogura, Haruo (JP) | 1982-07-27 | — | — | US | disclosed |
| US-4009264-A | COMPLEXES OF POLYSACCHARIDES OR DERIVATIVES THEREOF WITH REDUCED GLUTATHIONE AND PROCESS FOR PREPARING SAID COMPLEXES | MEITO SANGYO KABUSHIKI KAISHA (JA) | 1977-02-22 | — | — | US | disclosed |