Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL5321413 | 1.00 | LMNA (0.33) | LMNATSHRGABRR1CYP2C19THRB | |
| Glutarate SCHEMBL5770219 | 0.93 | LMNA (0.39) | LMNATSHRGABRR1THRBBLM | |
| Adipic Acid SCHEMBL11632441 | 0.93 | NFKB1 (0.42) | LMNATSHRGABRR1THRBBLM | |
| Histamine SCHEMBL1782847 | 0.91 | HRH4 (0.36) | LMNATSHRCYP2C19CYP2C9MTOR | |
| Histamine SCHEMBL8510036 | 0.91 | FFAR3 (0.39) | LMNATSHRCYP2C19HDAC3HDAC1 | |
| Histamine SCHEMBL4234179 | 0.89 | HRH4 (0.39) | LMNATSHRCYP2C19CYP2C9MTOR | |
| Histamine SCHEMBL9702159 | 0.88 | HRH4 (0.36) | TSHRGABRR1CYP2C19CYP2C9MTOR | |
| Histamine SCHEMBL8887482 | 0.88 | HRH4 (0.34) | TSHRCYP2C19CYP2C9MTORHRH4 | |
| Histamine SCHEMBL5840054 | 0.88 | HRH4 (0.38) | TSHRCYP2C19CYP2C9MTORHRH4 | |
| Hexanoate SCHEMBL9698455 | 0.87 | AKR1B1 (0.44) | TSHRKMT2AHDAC11TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874027-A2 | Electron beam curable resin composition and composite sheet material produced therefrom | OJI PAPER COMPANY LIMITED (JP) | 1998-10-28 | — | — | EP | claimed |
| US-4992360-A | Silver halide light-sensitive photographic material containing a novel yellow coupler | KONICA CORPORATION (JP) | 1991-02-12 | — | — | US | claimed |
| US-4883746-A | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-11-28 | — | — | US | claimed |
| US-4740455-A | Heat developable light-sensitive material containing polymethine | FUJI PHOTO FILM CO., LTD. (JP) | 1988-04-26 | — | — | US | claimed |
| EP-0073146-B1 | METHOD AND MATERIAL FOR THE FORMATION OF SILVER HALIDE COLOR PHOTOGRAPHIC IMAGE | KONICA CORPORATION (JP) | 1986-06-11 | — | — | EP | claimed |
| JP-1018600-A | — | — | None | — | — | JP | disclosed |
| US-10545424-B2 | Liquid developer and method of producing liquid developer | CANON KABUSHIKI KAISHA (JP) | 2020-01-28 | — | — | US | disclosed |
| US-20190094734-A1 | LIQUID DEVELOPER AND METHOD OF PRODUCING LIQUID DEVELOPER | CANON KABUSHIKI KAISHA (JP) | 2019-03-28 | — | — | US | disclosed |
| CN-108888757-A | Method for adjusting bile acid homeostasis and treating bile acid disorder and disease | 恩格姆生物制药公司 | 2018-11-27 | — | — | CN | disclosed |
| US-20170095502-A1 | Antimicrobial Metal-Binding Polymers | SARANGAPANI SHANTHA (US) | 2017-04-06 | — | — | US | disclosed |
| CN-102438656-B | Pretargeting kit, method and agents used therein | KONINKL PHILIPS ELECTRONICS NV | 2014-11-12 | — | — | CN | disclosed |
| CN-103945864-A | Truncated HIV envelope proteins (ENV), methods and compositions related thereto | ADVANCED BIOSCIENCE LAB INC | 2014-07-23 | — | — | CN | disclosed |
| US-4518683-A | A CARBOXAMIDO-UREIDO-SUBSTITUTED PHENOLIC CYAN COUPLER AND A PHTHALATE; PRESERVABILITY UNDER HIGH HEAT AND HUMIDITY AGING CONDITIONS | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1985-05-21 | — | — | US | disclosed |
| EP-0137271-A2 | Method of improving the light resistance of a dye image | KONICA CORPORATION (JP) | 1985-04-17 | — | — | EP | disclosed |
| EP-0136924-A2 | Silver halide light-sensitive colour photographic material | KONICA CORPORATION (JP) | 1985-04-10 | — | — | EP | disclosed |
| US-4489155-A | COLORLESS COMPETING COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1984-12-18 | — | — | US | disclosed |
| EP-0117105-A2 | Method for the processing of silver halide photographic light-sensitive materials | KONICA CORPORATION (JP) | 1984-08-29 | — | — | EP | disclosed |
| EP-0102839-A1 | Silver halide color photographic light-sensitive material | KONICA CORPORATION (JP) | 1984-03-14 | — | — | EP | disclosed |
| US-4396698-A | CROSSLINKED CATIONIC ADDITION COPOLYMERS AND HYDROPHOBIC PHENOLIC-TYPE COMPOUNDS; LIGHT SENSITIVE ELEMENTS | FUJI PHOTO FILM CO., LTD. (JP) | 1983-08-02 | — | — | US | disclosed |
| EP-0073146-A1 | Method and material for the formation of silver halide color photographic image | KONICA CORPORATION (JP) | 1983-03-02 | — | — | EP | disclosed |