Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL1782847 | 0.93 | HRH4 (0.36) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL5511684 | 0.93 | HRH4 (0.38) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL4234179 | 0.91 | HRH4 (0.39) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL5840054 | 0.89 | HRH4 (0.38) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL5321413 | 0.88 | LMNA (0.33) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL1680140 | 0.88 | LMNA (0.33) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL28074178 | 0.87 | HRH1 (0.42) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL28543874 | 0.87 | HRH4 (0.39) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL289072 | 0.87 | HRH4 (0.42) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL7444650 | 0.87 | HRH4 (0.42) | HRH4HRH3CYP2C9TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003961-A1 | IMIDO PEROXIDES AS INITIATORS OF POLYMERIZATION PROCESSES | AKZO NOBEL N.V. (NL) | 1997-02-06 | — | — | WO | disclosed |