SCHEMBL17830736

SCHEMBL17830736

O=C(Cn1c(=O)oc2cc(Cl)ccc21)OCc1cccc(O)c1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MIF P14174 4/20 0.52
POLB P06746 2/20 0.48
MAPT P10636 1/20 0.48
KMT2A Q03164 1/20 0.47
IDO1 P14902 4/20 0.47
ALDH1A1 P00352 2/20 0.47
USP2 O75604 1/20 0.47
PIK3CB P42338 1/20 0.46
TP53 P04637 2/20 0.46
LMNA P02545 2/20 0.46
CD74 P04233 2/20 0.44
TSHR P16473 1/20 0.44
CYP3A4 P08684 1/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TDP1 Q9NUW8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17830725 0.93 POLB (0.52) POLBMAPTKMT2AIDO1ALDH1A1
SCHEMBL17830715 0.90 PIK3CB (0.54) MIFPOLBMAPTKMT2AIDO1
SCHEMBL17830727 0.89 IDO1 (0.55) POLBMAPTKMT2AIDO1ALDH1A1
SCHEMBL17830723 0.89 PKM (0.53) MIFPOLBMAPTKMT2AIDO1
SCHEMBL17830720 0.88 TP53 (0.56) MIFPOLBMAPTKMT2AIDO1
SCHEMBL17830724 0.88 IDO1 (0.51) POLBMAPTKMT2AIDO1ALDH1A1
SCHEMBL17830729 0.87 CYP1A2 (0.45) POLBMAPTKMT2AIDO1ALDH1A1
SCHEMBL17830735 0.86 CCR2 (0.48) POLBMAPTKMT2AIDO1ALDH1A1
SCHEMBL17830733 0.84 MAPT (0.46) POLBMAPTKMT2AIDO1ALDH1A1
SCHEMBL17830726 0.83 IDO1 (0.55) POLBMAPTKMT2AIDO1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9943506-B2 BCL6 inhibitors as anticancer agents CORNELL UNIVERSITY (US) 2018-04-17 US disclosed
US-9943506-B2 BCL6 inhibitors as anticancer agents CORNELL UNIVERSITY (US) 2018-04-17 US disclosed
US-20160166549-A1 BCL6 INHIBITORS AS ANTICANCER AGENTS CORNELL UNIVERSITY 2016-06-16 US disclosed
US-20160166549-A1 BCL6 INHIBITORS AS ANTICANCER AGENTS CORNELL UNIVERSITY 2016-06-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160166549-A1 BCL6 INHIBITORS AS ANTICANCER AGENTS BCL6, BCL6B, BAZ2A MIF 3664/4885POLB 2366/4885MAPT 2263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.