Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Indocyanine Green Acid Form. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 1/20 | 0.91 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.91 |
| ▸ | PGR | P06401 | 1/20 | 0.91 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.91 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.91 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.91 |
| ▸ | DRD2 | P14416 | 1/20 | 0.91 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.91 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.91 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.91 |
| ▸ | CNR1 | P21554 | 1/20 | 0.91 |
| ▸ | DRD1 | P21728 | 1/20 | 0.91 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.91 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.91 |
| ▸ | HRH2 | P25021 | 1/20 | 0.91 |
| ▸ | HTR2C | P28335 | 1/20 | 0.91 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.91 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.91 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.91 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL17099464 | 1.00 | MLNR (0.91) | MLNRNR1I2PGRADRB1ADORA3 | |
| Indocyanine Green Acid Form SCHEMBL1783239 | 1.00 | MLNR (0.91) | MLNRNR1I2PGRADRB1ADORA3 | |
| Water SCHEMBL17219897 | 1.00 | MLNR (0.91) | MLNRNR1I2PGRADRB1ADORA3 | |
| Indocyanine Green Acid Form SCHEMBL10626491 | 1.00 | MLNR (0.91) | MLNRNR1I2PGRADRB1ADORA3 | |
| Water SCHEMBL30509135 | 1.00 | MLNR (0.91) | MLNRNR1I2PGRADRB1ADORA3 | |
| Indocyanine Green Acid Form SCHEMBL9809215 | 0.99 | MLNR (0.90) | MLNRNR1I2PGRADRB1ADORA3 | |
| Indocyanine Green Acid Form SCHEMBL15929439 | 0.99 | MLNR (0.93) | MLNRNR1I2PGRADRB1ADORA3 | |
| Indocyanine Green Acid Form SCHEMBL14198523 | 0.99 | MLNR (0.93) | MLNRNR1I2PGRADRB1ADORA3 | |
| SCHEMBL13127982 | 0.99 | MLNR (0.93) | MLNRNR1I2PGRADRB1ADORA3 | |
| Indocyanine Green Acid Form SCHEMBL12891571 | 0.99 | MLNR (0.93) | MLNRNR1I2PGRADRB1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200237670-A1 | DYE-STABILIZED NANOPARTICLES AND METHODS OF THEIR MANUFACTURE AND THERAPEUTIC USE | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2020-07-30 | — | — | US | disclosed |
| US-9121776-B2 | Welding arc apparel with UV or thermochromic activated images | LINCOLN GLOBAL, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| US-20130026150-A1 | WELDING ARC APPAREL WITH UV OR THEMOCHROMIC ACTIVATED IMAGES | LINCOLN GLOBAL, INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-8284385-B2 | Welding arc apparel with UV activated images | LINCOLN GLOBAL, INC. (US) | 2012-10-09 | — | — | US | disclosed |
| US-20110116076-A1 | WELDING ARC APPAREL WITH UV ACTIVATED IMAGES | LINCOLN GLOBAL, INC. (US) | 2011-05-19 | — | — | US | disclosed |
| US-20090169745-A1 | Nanoparticle based inks and methods of making the same | KIMBERLY-CLARK WORLDWIDE, INC. | 2009-07-02 | — | — | US | disclosed |
| US-20080152810-A1 | NANOPARTICLE BASED INKS AND METHODS OF MAKING THE SAME | KIMBERLY-CLARK WORDWIDE, INC. | 2008-06-26 | — | — | US | disclosed |
| EP-1412438-B1 | INK JET INK COMPOSITIONS CONTAINING FLUOROCHEMICAL SURFACTANTS | 3M INNOVATIVE PROPERTIES CO (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7371456-B2 | Nanoparticle based inks and methods of making the same | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7368487-B2 | Aqueous ink jet printable compositions | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-6017471-A | A RADIATION TRANSORBER CAPABLE OF MUTATING A COLORANT; LIGHT-STABLE COLORANT SYSTEM THAT IS MUTABLE BY EXPOSURE TO NARROW BAND-WIDTH RADIATION; COLORFASTNESS; DRY IMAGING; ?ERASING? COLORANTS; DATA STORAGE DISKS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2000-01-25 | — | — | US | disclosed |
| WO-1999036476-A2 | IMPROVED METHOD OF MAKING SULFANATOPHENYL SUBSTITUTED PORPHINES | KIMBERLY-CLARK WORLWIDE, INC. (US) | 1999-07-22 | — | — | WO | disclosed |
| US-5645964-A | STABILIZERS | KIMBERLY-CLARK CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5643356-A | UNSATURATED KETONE SENSITIZER BONDED TO RADIATION TRANSORBER WITH COLOR, MOLECULAR INCLUDENT AND VEHICLES | KIMBERLY-CLARK CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| US-5643701-A | Electrophotgraphic process utilizing mutable colored composition | KIMBERLY-CLARK CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| US-5631364-A | Labelled boronic acid derivatives | AXIS BIOCHEMICALS ASA (NO) | 1997-05-20 | — | — | US | disclosed |
| US-5616443-A | TONER FOR ELECTROGRAPHY | KIMBERLY-CLARK CORPORATION (US) | 1997-04-01 | — | — | US | disclosed |
| EP-0557357-B1 | LABELLING AGENTS COMPRISING BORONIC ACID CONJUGATES | AXIS BIOCHEMICALS AS (NO) | 1995-03-22 | — | — | EP | disclosed |
| EP-0557357-A1 | LABELLING AGENTS COMPRISING BORONIC ACID CONJUGATES. | COCKBAIN JULIAN R M (GB) | 1993-09-01 | — | — | EP | disclosed |
| WO-1992008722-A1 | LABELLING AGENTS COMPRISING BORONIC ACID CONJUGATES | AXIS RESEARCH AS (NO) | 1992-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200237670-A1 | DYE-STABILIZED NANOPARTICLES AND METHODS OF THEIR MANUFACTURE AND THERAPEUTIC USE | TP53, SCNN1B, HCCS | MLNR 3474/4885NR1I2 1114/4885PGR 1947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.