Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829888 | 0.87 | POLB (0.55) | SMN1; SMN2KMT2AMEN1MAPTLMNA | |
| SCHEMBL17833146 | 0.83 | USP1 (0.39) | SMN1; SMN2KMT2AMEN1SYKNR4A2 | |
| SCHEMBL17833154 | 0.83 | SYK (0.37) | SMN1; SMN2KMT2ASYKGAANR4A2 | |
| SCHEMBL17833237 | 0.81 | KMT2A (0.39) | SMN1; SMN2KMT2AMEN1MAPTSYK | |
| SCHEMBL17829856 | 0.80 | RAD52 (0.62) | KMT2AMEN1ACP1RAD52MAPK1 | |
| SCHEMBL17829887 | 0.78 | POLB (0.54) | KMT2AMEN1SYKNR4A2ACP1 | |
| SCHEMBL17830139 | 0.78 | RAD52 (0.57) | SMN1; SMN2KMT2AMEN1MAPTLMNA | |
| SCHEMBL17833189 | 0.77 | KMT2A (0.39) | SMN1; SMN2KMT2AMEN1MAPTSYK | |
| SCHEMBL17829588 | 0.76 | RAD52 (0.57) | KMT2AACP1RAD52MAPK1POLB | |
| SCHEMBL17829890 | 0.75 | RAD52 (0.53) | KMT2ASYKNR4A2ACP1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016094730-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS, INC. (US) | 2016-06-16 | — | — | WO | disclosed |