Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 9/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 9/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 8/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | PGK2 | P07205 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17833051 | 0.88 | S1PR2 (0.59) | S1PR2S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL4966489 | 0.86 | TYMS (0.53) | S1PR2S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL2045907 | 0.76 | S1PR2 (0.45) | S1PR2S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL5595395 | 0.74 | S1PR2 (0.59) | S1PR2S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL16625434 | 0.74 | S1PR2 (0.43) | S1PR2S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL1479560 | 0.74 | LMNA (0.59) | S1PR2S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL9792362 | 0.74 | TYMS (0.48) | S1PR2S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL2516244 | 0.74 | — | — | |
| SCHEMBL1359350 | 0.72 | — | — | |
| SCHEMBL8768407 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017214462-A2 | ANTI-CD98 ANTIBODIES AND ANTIBODY DRUG CONJUGATES | ABBVIE INC. (US) | 2017-12-14 | — | — | WO | disclosed |
| WO-2017214282-A1 | ANTI-EGFR ANTIBODY DRUG CONJUGATES | ABBVIE INC. (US) | 2017-12-14 | — | — | WO | disclosed |
| WO-2017214335-A1 | ANTI-B7-H3 ANTIBODIES AND ANTIBODY DRUG CONJUGATES | ABBVIE INC. (US) | 2017-12-14 | — | — | WO | disclosed |
| WO-2016094509-A1 | BCL XL INHIBITORY COMPOUNDS HAVING LOW CELL PERMEABILITY AND ANTIBODY DRUG CONJUGATES INCLUDING THE SAME | ABBVIE INC. (US) | 2016-06-16 | — | — | WO | disclosed |