Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | PREP | P48147 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | YAP1 | P46937 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19639228 | 1.00 | CTRB1 (0.60) | CTRB1NPSR1ALDH1A1KDM4ELMNA | |
| SCHEMBL19639223 | 0.89 | CTRB1 (0.67) | CTRB1NPSR1ALDH1A1KDM4ELMNA | |
| SCHEMBL19678646 | 0.88 | MMEL1 (0.49) | CTRB1ALDH1A1L3MBTL1ATMYAP1 | |
| SCHEMBL630484 | 0.84 | CTRB1 (0.56) | CTRB1NPSR1ALDH1A1KDM4ELMNA | |
| SCHEMBL629894 | 0.84 | CTRB1 (0.56) | CTRB1NPSR1ALDH1A1KDM4ELMNA | |
| SCHEMBL17822339 | 0.84 | ITGB3 (0.57) | ALDH1A1YAP1KMT2ATSHRMEN1 | |
| SCHEMBL17822338 | 0.84 | ITGB3 (0.57) | ALDH1A1YAP1KMT2ATSHRMEN1 | |
| SCHEMBL10346855 | 0.83 | CTRB1 (0.62) | CTRB1NPSR1ALDH1A1KDM4ELMNA | |
| SCHEMBL23499864 | 0.83 | ITGB1 (0.56) | LMNAYAP1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL19639216 | 0.83 | ITGB1 (0.56) | LMNAYAP1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107206085-B | Using alpha9Migration and release of HSCs for integrin antagonists and CXCR4 antagonists | 联邦科学和工业研究组织 | 2022-01-28 | — | — | CN | disclosed |
| US-20170348375-A1 | DISLODGEMENT AND RELEASE OF HSC FROM THE BONE MARROW STEM CELL NICHE USING ALPHA9 INTEGRIN ANTAGONISTS | COMMW SCIENT IND RES ORG (AU) | 2017-12-07 | — | — | US | disclosed |
| US-20170348375-A1 | DISLODGEMENT AND RELEASE OF HSC FROM THE BONE MARROW STEM CELL NICHE USING ALPHA9 INTEGRIN ANTAGONISTS | COMMW SCIENT IND RES ORG (AU) | 2017-12-07 | — | — | US | disclosed |
| US-20170340693-A1 | DISLODGEMENT AND RELEASE OF HSC USING ALPHA 9 INTEGRIN ANTAGONIST AND CXCR4 ANTAGONIST | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2017-11-30 | — | — | US | disclosed |
| US-20170340693-A1 | DISLODGEMENT AND RELEASE OF HSC USING ALPHA 9 INTEGRIN ANTAGONIST AND CXCR4 ANTAGONIST | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2017-11-30 | — | — | US | disclosed |
| WO-2016090403-A1 | DISLODGEMENT AND RELEASE OF HSC FROM THE BONE MARROW STEM CELL NICHE USING ALPHA9 INTEGRIN ANTAGONISTS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348375-A1 | DISLODGEMENT AND RELEASE OF HSC FROM THE BONE MARROW STEM CELL NICHE USING ALPHA9 INTEGRIN ANTAGONISTS | CXCL12, BST2, CCR9 | CTRB1 2139/4885NPSR1 757/4885ALDH1A1 401/4885 |
| US-20170340693-A1 | DISLODGEMENT AND RELEASE OF HSC USING ALPHA 9 INTEGRIN ANTAGONIST AND CXCR4 ANTAGONIST | CXCL12, CXCR4, CCR9 | CTRB1 2751/4885NPSR1 482/4885ALDH1A1 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.