SCHEMBL17833282

SCHEMBL17833282

CNCCCNc1nc(-c2cc(Br)cc(C(F)(F)F)c2)nc2c(F)cccc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SYK P43405 3/20 0.39
HMOX1 P09601 1/20 0.35
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
KCNH2 Q12809 2/20 0.35
CTSK P43235 1/20 0.35
ACP1 P24666 1/20 0.34
S1PR1 P21453 1/20 0.33
S1PR3 Q99500 1/20 0.33
PRKCI P41743 1/20 0.33
TBK1 Q9UHD2 1/20 0.33
RAD52 P43351 1/20 0.33
KMT2A Q03164 1/20 0.33
XPO1 O14980 1/20 0.33
CYP3A4 P08684 2/20 0.33
UBE2N P61088 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
CD38 P28907 1/20 0.33
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17833281 0.92 SYK (0.38) SYKHMOX1ALDH1A1KDM4EGAA
SCHEMBL17833286 0.91 SYK (0.38) SYKHMOX1ALDH1A1KDM4EGAA
SCHEMBL17833279 0.90 CTNNB1 (0.37) SYKHMOX1ALDH1A1KDM4EGAA
SCHEMBL17829865 0.89 ALDH1A1 (0.46) SYKALDH1A1KCNH2RAD52KMT2A
SCHEMBL17833143 0.83 PRKCI (0.34) SYKKCNH2CTSKS1PR1S1PR3
SCHEMBL17833283 0.83 SYK (0.40) SYKALDH1A1KDM4EGAAKCNH2
SCHEMBL17829946 0.83 SYK (0.47) SYKHMOX1ALDH1A1KDM4EGAA
SCHEMBL17833152 0.82 ACP1 (0.42) SYKALDH1A1KDM4EGAAACP1
SCHEMBL17833161 0.81 KMT2A (0.40) SYKALDH1A1KDM4EGAAKCNH2
SCHEMBL17829870 0.81 ALDH1A1 (0.47) SYKALDH1A1KCNH2RAD52KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016094730-A1 HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS SYNERECA PHARMACEUTICALS, INC. (US) 2016-06-16 WO disclosed