Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | VHL | P40337 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12630133 | 0.88 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2VHLGLAADORA2B | |
| SCHEMBL209226 | 0.84 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2VHLGLAADORA2B | |
| SCHEMBL6431541 | 0.84 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2VHLGLAADORA2B | |
| SCHEMBL2402704 | 0.82 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2VHLADORA2BADORA3 | |
| SCHEMBL1896996 | 0.81 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2VHLGLAADORA2B | |
| SCHEMBL16848164 | 0.80 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2VHLGLAADORA2B | |
| SCHEMBL21174073 | 0.80 | NPC1 (0.61) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 | |
| SCHEMBL22885243 | 0.80 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2VHLGLAADORA2B | |
| SCHEMBL1430802 | 0.79 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2VHLGLAADORA2B | |
| SCHEMBL9893155 | 0.79 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2VHLPKMEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362184-A1 | PRO-SURVIVAL COMPOUNDS | HERIOT-WATT UNIVERSITY (GB) | 2017-12-21 | — | — | US | disclosed |
| WO-2016092327-A1 | PRO-SURVIVAL COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362184-A1 | PRO-SURVIVAL COMPOUNDS | MCL1, MKI67, MORF4L1 | ALDH1A1 95/4885SMN1; SMN2 10/4885VHL 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.