Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 0.82 |
| ▸ | RAB9A | P51151 | 6/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.61 |
| ▸ | CASP3 | P42574 | 2/20 | 0.61 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22192264 | 0.87 | RAB9A (0.94) | MEN1KMT2ARXFP1LMNANPC1 | |
| SCHEMBL4964241 | 0.84 | NPC1 (1.00) | MEN1KMT2ARXFP1LMNANPC1 | |
| SCHEMBL13393187 | 0.83 | RAB9A (0.86) | MEN1KMT2ARXFP1LMNANPC1 | |
| SCHEMBL21370445 | 0.83 | NR1H4 (0.82) | MEN1KMT2ARXFP1LMNANPC1 | |
| SCHEMBL11879987 | 0.82 | RAB9A (0.84) | MEN1KMT2ARXFP1LMNANPC1 | |
| SCHEMBL12020864 | 0.82 | MEN1 (0.70) | MEN1KMT2ARXFP1LMNANPC1 | |
| SCHEMBL12310177 | 0.81 | RAB9A (0.73) | MEN1KMT2ARXFP1LMNANPC1 | |
| SCHEMBL12044019 | 0.81 | NPC1 (0.82) | MEN1KMT2ARXFP1LMNANPC1 | |
| SCHEMBL15821075 | 0.81 | SMPD1 (0.69) | MEN1KMT2ARXFP1LMNANPC1 | |
| SCHEMBL19831608 | 0.80 | HDAC1 (0.75) | MEN1KMT2ARXFP1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160171150-A1 | Chemical Modulators of Pro-Apoptotic BAX and BCL-2 Polypeptides | DANA-FARBER CANCER INSTITUTE, INC. | 2016-06-16 | — | — | US | disclosed |