Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.36 |
| ▸ | ITGAV | P06756 | 5/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.33 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.33 |
| ▸ | MAP3K4 | Q9Y6R4 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19485685 | 1.00 | ENPP2 (0.37) | ENPP2ITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL17834943 | 0.92 | ITGB3 (0.39) | ENPP2ITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL17834968 | 0.92 | ITGB3 (0.37) | ENPP2ITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL19485674 | 0.92 | ITGB3 (0.37) | ENPP2ITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL19485739 | 0.92 | ITGB1 (0.39) | ENPP2ITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL17834960 | 0.92 | ITGB1 (0.39) | ENPP2ITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL17532296 | 0.91 | ALDH1A1 (0.35) | ENPP2ITGB3ITGA2BMC4RPRCP | |
| SCHEMBL22167240 | 0.91 | ALDH1A1 (0.35) | ENPP2ITGB3ITGA2BMC4RPRCP | |
| SCHEMBL17834958 | 0.91 | ITGB3 (0.40) | ENPP2ITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL17834817 | 0.91 | ITGB3 (0.40) | ENPP2ITGB3ITGA2BITGB1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10034886-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2018-07-31 | — | — | US | disclosed |
| US-10034886-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2018-07-31 | — | — | US | disclosed |
| US-20180021346-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | RECEPTOS LLC | 2018-01-25 | — | — | US | disclosed |
| US-9795613-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2017-10-24 | — | — | US | disclosed |
| US-9795613-B2 | GLP-1 receptor modulators | CELGENE INTERNATIONAL II SÀRL (CH) | 2017-10-24 | — | — | US | disclosed |
| WO-2016094729-A1 | GLP-1 RECEPTOR MODULATORS | CELGENE INTERNATIONAL II SARL (CH) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180021346-A1 | NOVEL GLP-1 RECEPTOR MODULATORS | GLP1R, GIPR, NPY1R | ENPP2 291/4885ITGB3 4025/4885ITGA2B 4142/4885 |
| US-10034886-B2 | GLP-1 receptor modulators | GLP1R, GIPR, GCGR | ENPP2 350/4885ITGB3 3678/4885ITGA2B 4134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.