Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 12/20 | 0.57 |
| ▸ | HTR1D | P28221 | 3/20 | 0.53 |
| ▸ | HTR1B | P28222 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14981045 | 0.85 | RAPGEF4 (0.59) | RAPGEF4HTR1DHTR1BPOLB | |
| SCHEMBL22051001 | 0.82 | RAPGEF4 (0.55) | RAPGEF4HTR1DHTR1BPOLBTSHR | |
| SCHEMBL25154012 | 0.81 | POLB (0.48) | RAPGEF4HTR1DHTR1BPOLBTSHR | |
| SCHEMBL15312216 | 0.80 | RAPGEF4 (0.49) | RAPGEF4HTR1DHTR1BTSHRHPGD | |
| SCHEMBL20404366 | 0.80 | RAPGEF4 (0.70) | RAPGEF4HTR1DHTR1BTSHRHPGD | |
| SCHEMBL8664743 | 0.79 | POLB (0.57) | HTR1DHTR1BPOLBTSHRHPGD | |
| SCHEMBL19194234 | 0.79 | POLB (0.46) | RAPGEF4HTR1DHTR1BPOLBTSHR | |
| Hydrochloric Acid SCHEMBL26097882 | 0.77 | POLB (0.56) | RAPGEF4HTR1DHTR1BPOLBTSHR | |
| SCHEMBL3220409 | 0.77 | RAPGEF4 (0.50) | RAPGEF4HTR1DHTR1BPOLBHPGD | |
| SCHEMBL12251281 | 0.74 | POLB (0.52) | HTR1DHTR1BPOLBTSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10683453-B2 | Organic compounds with soluble groups | MERCK PATENT GMBH (DE) | 2020-06-16 | — | — | US | disclosed |
| EP-3230403-B1 | ORGANIC COMPOUNDS WITH SOLUBLE GROUPS | MERCK PATENT GMBH (DE) | 2019-10-09 | — | — | EP | disclosed |
| US-20170369773-A1 | ORGANIC COMPOUNDS WITH SOLUBLE GROUPS | UDC IRELAND LIMITED (IE) | 2017-12-28 | — | — | US | disclosed |
| WO-2016091353-A1 | ORGANIC COMPOUNDS WITH SOLUBLE GROUPS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369773-A1 | ORGANIC COMPOUNDS WITH SOLUBLE GROUPS | SLCO4C1, SLCO1B3, SLCO2B1 | RAPGEF4 4455/4885HTR1D 2175/4885HTR1B 1425/4885 |
| US-10683453-B2 | Organic compounds with soluble groups | SLCO4C1, SLCO1B3, SLCO2B1 | RAPGEF4 4455/4885HTR1D 2175/4885HTR1B 1425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.