SCHEMBL20404366

SCHEMBL20404366

Cc1ccc(Nc2c(C)cc(C(C)(C)C)cc2C)cc1

nearest known ligand 0.70

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 14/20 0.70
TSHR P16473 1/20 0.48
MEN1 O00255 1/20 0.46
GAA P10253 1/20 0.46
G6PD P11413 1/20 0.46
KMT2A Q03164 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
HTR1D P28221 1/20 0.44
HTR1B P28222 1/20 0.44
HPGD P15428 1/20 0.43
NPC1 O15118 1/20 0.42
MAPT P10636 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14981045 0.94 RAPGEF4 (0.59) RAPGEF4HTR1DHTR1B
SCHEMBL22051001 0.90 RAPGEF4 (0.55) RAPGEF4TSHRHTR1DHTR1B
SCHEMBL22212768 0.87 RAPGEF4 (0.54) RAPGEF4TSHRMEN1GAAG6PD
SCHEMBL17858124 0.86 RAPGEF4 (0.68) RAPGEF4
SCHEMBL3220409 0.85 RAPGEF4 (0.50) RAPGEF4MEN1KMT2AL3MBTL1HTR1D
SCHEMBL15312216 0.84 RAPGEF4 (0.49) RAPGEF4TSHRMEN1KMT2AL3MBTL1
SCHEMBL15188815 0.83 RAPGEF4 (1.00) RAPGEF4
SCHEMBL7618028 0.81 RAPGEF4 (0.79) RAPGEF4MEN1GAAG6PDKMT2A
SCHEMBL24084610 0.80 RAPGEF4 (0.46) RAPGEF4TSHRHTR1DHTR1BHPGD
SCHEMBL17835019 0.80 RAPGEF4 (0.57) RAPGEF4TSHRHTR1DHTR1BHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3351576-B1 POLYMER COMPOUND AND LIGHT-EMITTING ELEMENT USING SAME SUMITOMO CHEMICAL CO (JP) 2020-05-06 EP disclosed
EP-3351576-A1 POLYMER COMPOUND AND LIGHT-EMITTING ELEMENT USING SAME Sumitomo Chemical Company Limited (JP) 2018-07-25 EP disclosed