Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | IL1B | P01584 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17835252 | 1.00 | P2RX7 (0.32) | P2RX7ADAMTS4IL1B | |
| SCHEMBL17835249 | 1.00 | P2RX7 (0.32) | P2RX7ADAMTS4IL1B | |
| SCHEMBL17818969 | 0.82 | FUCA1 (0.32) | P2RX7ADAMTS4IL1B | |
| SCHEMBL17834113 | 0.80 | P2RX7 (0.31) | P2RX7ADAMTS4IL1B | |
| SCHEMBL17834114 | 0.80 | P2RX7 (0.31) | P2RX7ADAMTS4IL1B | |
| SCHEMBL17834111 | 0.80 | P2RX7 (0.31) | P2RX7ADAMTS4IL1B | |
| SCHEMBL9941609 | 0.77 | ESR1 (0.38) | — | |
| SCHEMBL3079816 | 0.77 | ESR1 (0.38) | — | |
| SCHEMBL15382208 | 0.74 | — | — | |
| SCHEMBL17858281 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168090-A1 | NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168090-A1 | NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES | P2RX3, P2RX7, P2RX2 | P2RX7 2/4885ADAMTS4 3978/4885IL1B 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.