Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 11/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2671847 | 1.00 | MAPT (0.50) | MAPTCTSKMIFRAB9ANPC1 | |
| SCHEMBL5768258 | 0.84 | CTSK (0.46) | MAPTCTSKMIFRAB9ANPC1 | |
| SCHEMBL13302740 | 0.83 | CTSK (0.40) | MAPTCTSKMIFRAB9ANPC1 | |
| SCHEMBL5544738 | 0.79 | CTSK (0.45) | MAPTCTSKMIFRAB9ANPC1 | |
| SCHEMBL8829341 | 0.79 | CTSK (0.45) | MAPTCTSKMIFRAB9ANPC1 | |
| SCHEMBL8829337 | 0.79 | CTSK (0.45) | MAPTCTSKMIFRAB9ANPC1 | |
| SCHEMBL12731332 | 0.78 | RAB9A (0.49) | MAPTCTSKMIFRAB9ANPC1 | |
| SCHEMBL2943326 | 0.78 | MIF (0.53) | MAPTCTSKMIFRAB9ANPC1 | |
| SCHEMBL2943324 | 0.78 | MIF (0.53) | MAPTCTSKMIFRAB9ANPC1 | |
| SCHEMBL2683738 | 0.76 | MIF (0.51) | MAPTCTSKMIFRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11401244-B2 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (US) | 2022-08-02 | — | — | US | disclosed |
| US-20190315693-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RES TRIANGLE INST (US) | 2019-10-17 | — | — | US | disclosed |
| US-10377718-B2 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (US) | 2019-08-13 | — | — | US | disclosed |
| US-20160207889-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2016-07-21 | — | — | US | disclosed |
| US-8304556-B2 | Thiazolyl-dihydro-indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-06 | — | — | US | disclosed |
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| CN-102015728-A | Thiazolyl-dihydro-indazoles | BOEHRINGER INGELHEIM INT | 2011-04-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207889-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | MAPT 4339/4885CTSK 1229/4885MIF 3915/4885 |
| US-11401244-B2 | Apelin receptor (APJ) agonists and uses thereof | APLNR, AP1G1, APMAP | MAPT 4339/4885CTSK 1229/4885MIF 3915/4885 |
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | MAPT 2509/4885CTSK 3429/4885MIF 159/4885 |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | MAPT 2509/4885CTSK 3429/4885MIF 159/4885 |
| US-10377718-B2 | Apelin receptor (APJ) agonists and uses thereof | APLNR, AP1G1, APMAP | MAPT 4339/4885CTSK 1229/4885MIF 3915/4885 |
| US-20190315693-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | MAPT 4339/4885CTSK 1229/4885MIF 3915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.