Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MGAM | O43451 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27303537 | 1.00 | ALDH1A1 (0.71) | ALDH1A1PABPC1ALOX15HTTPLK1 | |
| Quinoline SCHEMBL28752073 | 0.98 | ALDH1A1 (0.68) | ALDH1A1PABPC1ALOX15HTTPLK1 | |
| Quinoline SCHEMBL28174345 | 0.98 | ALDH1A1 (0.68) | ALDH1A1PABPC1ALOX15HTTPLK1 | |
| Quinoline SCHEMBL27716145 | 0.98 | ALDH1A1 (0.68) | ALDH1A1PABPC1ALOX15HTTPLK1 | |
| Quinoline SCHEMBL28300609 | 0.98 | ALDH1A1 (0.68) | ALDH1A1PABPC1ALOX15HTTPLK1 | |
| Quinoline SCHEMBL28118663 | 0.98 | ALDH1A1 (0.68) | ALDH1A1PABPC1ALOX15HTTPLK1 | |
| Quinoline SCHEMBL27635795 | 0.94 | ALDH1A1 (0.74) | ALDH1A1PABPC1ALOX15HTTPLK1 | |
| Quinoline SCHEMBL28374232 | 0.93 | ALDH1A1 (0.61) | ALDH1A1PABPC1ALOX15HTTPLK1 | |
| Quinoline SCHEMBL27796383 | 0.92 | ALDH1A1 (0.71) | ALDH1A1PABPC1ALOX15HTTPLK1 | |
| Quinoline SCHEMBL5283313 | 0.91 | ALDH1A1 (0.77) | ALDH1A1PABPC1ALOX15HTTPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117343045-A | Synthesis method of 2- (pyridine/quinoline-2-yl) -3- (1H-indol-3-yl) propionate compound | 南方医科大学 | 2024-01-05 | — | — | CN | claimed |
| CN-117069658-A | Preparation method of 4-oxo-6-methoxy-3- (2, 3-dichlorophenyl) methyl-1 (4H) -quinolineacetic acid | 宁夏康亚药业股份有限公司 | 2023-11-17 | — | — | CN | claimed |
| CN-113372268-A | 4-oxo-6-methoxy-3- (2, 3-dichlorophenyl) methyl-1 (4H) quinolineacetic acid metabolites | 宁夏康亚药业股份有限公司 | 2021-09-10 | — | — | CN | claimed |
| CN-108396325-B | Water-soluble weldable nickel protective agent | 广州天至环保科技有限公司 | 2020-07-03 | — | — | CN | claimed |
| CN-107891232-B | Lead-free halogen-free soldering paste and preparation method thereof | 江苏广昇新材料有限公司 | 2020-03-17 | — | — | CN | claimed |
| CN-108396325-A | A kind of solderable nickel protective agent of water solubility | 广州天至环保科技有限公司 | 2018-08-14 | — | — | CN | claimed |
| CN-107891232-A | A kind of lead-free and halogen-free weld-aiding cream and preparation method thereof | 江苏广昇新材料有限公司 | 2018-04-10 | — | — | CN | claimed |
| CN-107759523-A | A kind of stearic amide ethyl imidazol(e) quinoline acetate process units of 2 heptadecyl 3 | 成都东电艾尔科技有限公司 | 2018-03-06 | — | — | CN | claimed |
| CN-104761494-B | A kind of preparation method of (S) or (R) 1 (4 methoxy-benzyl) 1,2,3,4,5,6,7,8 octahydro isoquinolin | 上海医药工业研究院 | 2018-01-19 | — | — | CN | claimed |
| CN-205974332-U | 2 heptadecyl 3 stearic amide ethyl imidazol(e) quinoline acetate apparatus for producing | 衢州普林千叶电子科技有限公司 | 2017-02-22 | — | — | CN | claimed |
| CN-104012782-A | Creep powdery feed for suckling pig | ANHUI ZHUANGDA FEED CO LTD | 2014-09-03 | — | — | CN | claimed |
| CN-101613280-B | Preparation method of felodipine synthetic intermediate methyl 2-(2,3-dichlorobenzylidine)acetoacetate | HEFEI LIFANG MEDICATION CO LTD | 2012-10-17 | — | — | CN | claimed |
| CN-101613280-A | Felodipine synthetic intermediate 2, the preparation method of 3-dichlorin benzylidene methyl acetoacetate | HEFEI LIFANG MEDICATION CO LTD | 2009-12-30 | — | — | CN | claimed |
| CN-100463668-C | Reversibly hot gelified water soluble medicine composition | PEIXUE LING (CN) | 2009-02-25 | — | — | CN | claimed |
| CN-1706365-A | Reversibly hot gelified water soluble medicine composition | LING PEIXUE (CN) | 2005-12-14 | — | — | CN | claimed |
| CN-1451009-A | Glucocortiocoid-selective antinflammatory agents | ABBOTT LAB (US) | 2003-10-22 | — | — | CN | claimed |
| CN-1048393-C | Aqueous drug composition having property of reversible thermosetting gelation | WAKAMOTO PHARMA CO LTD (JP) | 2000-01-19 | — | — | CN | claimed |
| CN-1035823-C | Process for preparing latent catalysts for curing epoxy resins | DOW CHEMICAL CO (US) | 1997-09-10 | — | — | CN | claimed |
| CN-1097593-A | Aqueous drug composition having property of reversible thermosetting gelation | WAKAMOTO PHARMA CO LTD (JP) | 1995-01-25 | — | — | CN | claimed |
| CN-1056699-A | Latent catalysts and cure-inhibited epoxy resin compositions and laminates made therefrom | DOW CHEMICAL CO (US) | 1991-12-04 | — | — | CN | claimed |