Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27303537 | 0.93 | ALDH1A1 (0.71) | ALDH1A1KDM4EPABPC1ALOX15HTT | |
| Quinoline SCHEMBL1783847 | 0.93 | ALDH1A1 (0.71) | ALDH1A1KDM4EPABPC1ALOX15HTT | |
| Quinoline SCHEMBL28300609 | 0.91 | ALDH1A1 (0.68) | ALDH1A1KDM4EPABPC1ALOX15HTT | |
| Quinoline SCHEMBL28174345 | 0.91 | ALDH1A1 (0.68) | ALDH1A1KDM4EPABPC1ALOX15HTT | |
| Quinoline SCHEMBL27716145 | 0.91 | ALDH1A1 (0.68) | ALDH1A1KDM4EPABPC1ALOX15HTT | |
| Quinoline SCHEMBL28752073 | 0.91 | ALDH1A1 (0.68) | ALDH1A1KDM4EPABPC1ALOX15HTT | |
| Quinoline SCHEMBL28118663 | 0.91 | ALDH1A1 (0.68) | ALDH1A1KDM4EPABPC1ALOX15HTT | |
| Quinoline SCHEMBL21535 | 0.91 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12NAMPTBCAT1 | |
| Quinoline SCHEMBL5874241 | 0.91 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12NAMPTBCAT1 | |
| Quinoline SCHEMBL29710686 | 0.91 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12NAMPTBCAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114223661-A | Use of acyclic picolinamides as fungicides for controlling phytopathogenic fungi in row crops | 美国陶氏益农公司 | 2022-03-25 | — | — | CN | disclosed |
| CN-111182791-B | Use of acyclic picolinamides as fungicides for controlling phytopathogenic fungi in vegetables | 美国陶氏益农公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-111132550-B | Use of acyclic picolinamides as fungicides for controlling phytopathogenic fungi in row crops | 美国陶氏益农公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-110996665-B | Use of acyclic picolinamides as fungicides against fungal diseases on turfgrass | 陶氏益农公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-110933931-B | Use of acyclic picolinamides as fungicides for controlling phytopathogenic fungi in orchards, vineyards and plantation crops | 美国陶氏益农公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-111182791-A | Use of acyclic picolinamides as fungicides for controlling phytopathogenic fungi in vegetables | 美国陶氏益农公司 | 2020-05-19 | — | — | CN | disclosed |
| CN-111132550-A | Use of acyclic picolinamides as fungicides for controlling phytopathogenic fungi in row crops | 美国陶氏益农公司 | 2020-05-08 | — | — | CN | disclosed |
| CN-110933931-A | Use of acyclic picolinamides as fungicides for controlling phytopathogenic fungi in orchards, vineyards and plantation crops | 美国陶氏益农公司 | 2020-03-27 | — | — | CN | disclosed |