Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MGAM | O43451 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL372690 | 1.00 | ALDH1A1 (0.77) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL5874493 | 1.00 | ALDH1A1 (0.77) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL28197315 | 0.98 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL5875372 | 0.93 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL27473723 | 0.93 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL5272119 | 0.93 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL2201840 | 0.93 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL5875384 | 0.93 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL7208557 | 0.93 | ALDH1A1 (0.90) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL1783847 | 0.91 | ALDH1A1 (0.71) | ALDH1A1PABPC1MEN1KMT2AMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348001-B1 | CLEAR LACQUER COAT | BOLLIG & KEMPER GMBH & CO KG (DE) | 2007-12-05 | — | — | EP | disclosed |
| EP-1341833-B1 | ACRYLATE-BASED COATING COMPOSITION CONTAINING FLUOROMODIFIED POLYMERS | BOLLIG & KEMPER GMBH & CO KG (DE) | 2006-01-25 | — | — | EP | disclosed |
| EP-1348001-A1 | CLEAR LACQUER COAT | Bollig & Kemper GmbH & Co. KG (DE) | 2003-10-01 | — | — | EP | disclosed |
| EP-1341833-A1 | ACRYLATE-BASED COATING COMPOSITION CONTAINING FLUOROMODIFIED POLYMERS | Bollig & Kemper GmbH & Co. KG (DE) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002044237-A1 | CLEAR LACQUER COAT | BOLLIG & KEMPER GMBH & CO. KG (DE) | 2002-06-06 | — | — | WO | disclosed |
| WO-2002044235-A1 | ACRYLATE-BASED COATING COMPOSITION CONTAINING FLUOROMODIFIED POLYMERS | BOLLIG & KEMPER GMBH & CO. KG (DE) | 2002-06-06 | — | — | WO | disclosed |
| EP-0813552-B1 | MODIFIED ACRYL COPOLYMER | BOLLIG & KEMPER GMBH & CO KG (DE) | 1998-12-23 | — | — | EP | disclosed |