Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17842308 | 0.93 | DRD2 (0.50) | DRD2ACKR3DRD3SMN1; SMN2OPRM1 | |
| SCHEMBL17842183 | 0.82 | DRD2 (0.51) | DRD2OPRM1OPRD1 | |
| SCHEMBL17842566 | 0.77 | ALDH1A1 (0.44) | SMN1; SMN2 | |
| SCHEMBL23356487 | 0.76 | DRD2 (0.83) | DRD2OPRM1OPRD1 | |
| SCHEMBL17842013 | 0.76 | DRD2 (0.83) | DRD2OPRM1OPRD1 | |
| SCHEMBL23356484 | 0.76 | DRD2 (0.83) | DRD2OPRM1OPRD1 | |
| SCHEMBL17842392 | 0.76 | CHRM1 (0.54) | MAPTSMN1; SMN2 | |
| SCHEMBL17842367 | 0.75 | SMN1; SMN2 (0.54) | POLBMAPTSMN1; SMN2TSHREPHX2 | |
| SCHEMBL17842070 | 0.75 | DRD2 (0.57) | DRD2 | |
| SCHEMBL17842252 | 0.71 | CTSD (0.39) | DRD2DRD3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233799-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100823-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |