Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844307 | 0.94 | MAPT (0.47) | MAPTSMN1; SMN2HSP90AA1CYP1A2CYP2C9 | |
| SCHEMBL17844388 | 0.87 | THRA (0.42) | MAPTSMN1; SMN2HTTNPSR1KMT2A | |
| SCHEMBL17844305 | 0.86 | MAPT (0.42) | MAPTSMN1; SMN2HSP90AA1CYP1A2CYP2C9 | |
| SCHEMBL17844306 | 0.80 | NPC1 (0.59) | MAPTSMN1; SMN2HSP90AA1CYP1A2CYP2C9 | |
| SCHEMBL2149738 | 0.78 | MAPT (0.66) | MAPTSMN1; SMN2HSP90AA1CYP1A2CYP2C9 | |
| SCHEMBL6622308 | 0.77 | MCHR1 (0.59) | MAPTSMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5767014 | 0.77 | MAPT (0.64) | MAPTSMN1; SMN2HSP90AA1CYP1A2CYP2C9 | |
| SCHEMBL5637060 | 0.76 | THRA (0.60) | MAPTSMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1015775 | 0.76 | MAPT (0.62) | MAPTSMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9544375 | 0.76 | HPGD (0.63) | MAPTSMN1; SMN2CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233847-A1 | AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex Suisse SA (CH) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016098005-A1 | AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2016-06-23 | — | — | WO | disclosed |