Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MGLL | Q99685 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767014 | 0.95 | MAPT (0.64) | MAPTPRSS1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL17149979 | 0.93 | KMT2A (0.63) | MAPTPRSS1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5216700 | 0.92 | MGLL (0.62) | MAPTPRSS1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL1011130 | 0.92 | MAPT (0.60) | MAPTPRSS1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL15595698 | 0.92 | MAPT (0.60) | MAPTPRSS1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL787576 | 0.91 | MAPT (0.59) | MAPTPRSS1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL14930505 | 0.91 | SMPD1 (0.65) | MAPTPRSS1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL9798517 | 0.91 | MAPT (0.59) | MAPTPRSS1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL4376688 | 0.91 | MAPT (0.59) | MAPTPRSS1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL4375986 | 0.91 | MAPT (0.59) | MAPTPRSS1KMT2ACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11779650-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-10-10 | — | — | US | disclosed |
| US-11779650-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-10-10 | — | — | US | disclosed |
| US-11771775-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-10-03 | — | — | US | disclosed |
| US-11771775-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-10-03 | — | — | US | disclosed |
| US-11690918-B2 | Pyrrolobenzodiazepine-anti-CD22 antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-07-04 | — | — | US | disclosed |
| US-11690918-B2 | Pyrrolobenzodiazepine-anti-CD22 antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-07-04 | — | — | US | disclosed |
| US-20230143309-A1 | PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES | MEDIMMUNE LIMITED (GB) | 2023-05-11 | — | — | US | disclosed |
| US-11517626-B2 | Pyrrolobenzodiazepine antibody conjugates | MEDIMMUNE LIMITED (GB) | 2022-12-06 | — | — | US | disclosed |
| US-20210187117-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | MEDIMMUNE LIMITED (GB) | 2021-06-24 | — | — | US | disclosed |
| US-20210137940-A1 | PYRROLOBENZODIAZEPINE-ANTI-PSMA ANTIBODY CONJUGATES | OWL ROCK OPPORTUNISTIC MASTER FUND I, L.P. | 2021-05-13 | — | — | US | disclosed |
| US-8367824-B2 | Reacting anthranilic acid with formic acid compound in presence of a catalyst and solvent | UBE INDUSTRIES LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| EP-1675857-B1 | PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND METHODS RELATED THERETO | US GOV HEALTH & HUMAN SERV (US) | 2011-07-13 | — | — | EP | disclosed |
| US-7834005-B2 | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-11-16 | — | — | US | disclosed |
| WO-2010043877-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |
| EP-1477481-B1 | PROCESS FOR PRODUCING QUINAZOLIN-4-ONE DERIVATIVE | UBE INDUSTRIES (JP) | 2009-07-22 | — | — | EP | disclosed |
| US-20090149449-A1 | PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND METHODS RELATED THERETO | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICE (US) | 2009-06-11 | — | — | US | disclosed |
| US-7511032-B2 | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-03-31 | — | — | US | disclosed |
| US-20070072846-A1 | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto | SPIROGEN SARL (CH) | 2007-03-29 | — | — | US | disclosed |
| US-20050080262-A1 | Process for producing quinazolin-4-one derivative | UBE INDUSTRIES, LTD. (JP) | 2005-04-14 | — | — | US | disclosed |
| EP-1477481-A1 | PROCESS FOR PRODUCING QUINAZOLIN-4-ONE DERIVATIVE | Ube Industries, Ltd. (JP) | 2004-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11690918-B2 | Pyrrolobenzodiazepine-anti-CD22 antibody conjugates | CD22, CD2, CD2BP2 | MAPT 1953/4885PRSS1 1302/4885KMT2A 427/4885 |
| US-11779650-B2 | Pyrrolobenzodiazepine-antibody conjugates | IL2RA, CD4, IL2 | MAPT 1007/4885PRSS1 3836/4885KMT2A 1422/4885 |
| US-20090149449-A1 | PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND METHODS RELATED THERETO | CCNB1, NPY1R, CCNO | MAPT 3915/4885PRSS1 2528/4885KMT2A 3188/4885 |
| US-20210137940-A1 | PYRROLOBENZODIAZEPINE-ANTI-PSMA ANTIBODY CONJUGATES | PSMA2, PSMA7, FOLH1 | MAPT 514/4885PRSS1 2006/4885KMT2A 1144/4885 |
| US-20050080262-A1 | Process for producing quinazolin-4-one derivative | NQO2, SDHA, CYP3A4 | MAPT 4602/4885PRSS1 1196/4885KMT2A 1507/4885 |
| US-11771775-B2 | Pyrrolobenzodiazepine-antibody conjugates | CD79B, BCL6B, BCL6 | MAPT 575/4885PRSS1 3670/4885KMT2A 628/4885 |
| US-20070072846-A1 | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto | IPO7, RAB7A, GRB7 | MAPT 4508/4885PRSS1 2883/4885KMT2A 3756/4885 |
| US-20230143309-A1 | PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES | CD79B, H1-10, DRD1 | MAPT 831/4885PRSS1 4344/4885KMT2A 1344/4885 |
| US-11517626-B2 | Pyrrolobenzodiazepine antibody conjugates | CD79B, DRD1, H1-10 | MAPT 1115/4885PRSS1 4034/4885KMT2A 1456/4885 |
| US-20210187117-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | H1-10, DRD1, DRD2 | MAPT 933/4885PRSS1 4398/4885KMT2A 1203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.