Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 17/20 | 0.34 |
| ▸ | CDK9 | P50750 | 17/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844418 | 0.89 | LIMK1 (0.34) | — | |
| SCHEMBL17837904 | 0.89 | GRM1 (0.42) | CDK9 | |
| SCHEMBL17844432 | 0.89 | TRPV1 (0.33) | — | |
| SCHEMBL17837729 | 0.79 | GRM1 (0.44) | CCNT1CDK9 | |
| SCHEMBL17844574 | 0.79 | CHRM4 (0.35) | — | |
| SCHEMBL17837491 | 0.78 | GRM1 (0.41) | — | |
| SCHEMBL17837694 | 0.73 | GRM5 (0.47) | — | |
| SCHEMBL17837585 | 0.70 | ALDH1A1 (0.40) | — | |
| SCHEMBL28824082 | 0.70 | TRPV1 (0.34) | — | |
| SCHEMBL17844426 | 0.69 | KLKB1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233829-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | Pfizer Inc (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097918-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | PFIZER INC. (US) | 2016-06-23 | — | — | WO | disclosed |