Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 15/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844418 | 0.90 | LIMK1 (0.34) | TRPV1GRIA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17837491 | 0.89 | GRM1 (0.41) | CNR1 | |
| SCHEMBL17844397 | 0.89 | QDPR (0.35) | — | |
| SCHEMBL17837729 | 0.79 | GRM1 (0.44) | — | |
| SCHEMBL17837904 | 0.78 | GRM1 (0.42) | — | |
| SCHEMBL17837694 | 0.74 | GRM5 (0.47) | — | |
| SCHEMBL22013966 | 0.73 | MAPT (0.35) | ALDH1A1 | |
| SCHEMBL30908099 | 0.73 | MAPT (0.35) | ALDH1A1 | |
| SCHEMBL26720538 | 0.73 | KMT2A (0.34) | — | |
| SCHEMBL17837901 | 0.72 | DGAT1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233829-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | Pfizer Inc (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097918-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | PFIZER INC. (US) | 2016-06-23 | — | — | WO | disclosed |