Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | TEC | P42680 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17838057 | 0.84 | KDM4E (0.46) | AXLKDM4EHTTHPGDALDH1A1 | |
| SCHEMBL17844394 | 0.82 | SCD (0.37) | LMNASCDKDM5AKDM4EGLA | |
| SCHEMBL17837561 | 0.81 | HRH4 (0.42) | AXLNQO2SCN9A | |
| SCHEMBL16795183 | 0.77 | CCR2 (0.42) | LMNAKDM5AMAPT | |
| SCHEMBL17844419 | 0.76 | CNR2 (0.48) | AXLSCDKDM5AEGFRTEC | |
| SCHEMBL21714255 | 0.68 | SLC18A3 (0.55) | LMNAKDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL27577295 | 0.68 | TNIK (0.42) | LMNAKDM5AKDM4EHTTHPGD | |
| SCHEMBL17837370 | 0.68 | KDM4E (0.48) | KDM4EHTTHPGDALDH1A1HSD17B10 | |
| SCHEMBL17844433 | 0.67 | GRM2 (0.38) | SCD | |
| SCHEMBL9943901 | 0.66 | CNR2 (0.49) | LMNAKDM5AKDM4EALDH1A1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233829-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | Pfizer Inc (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097918-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | PFIZER INC. (US) | 2016-06-23 | — | — | WO | disclosed |