Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | TEC | P42680 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22540920 | 0.85 | LMNA (0.41) | SRCPOLBLMNA | |
| SCHEMBL17844407 | 0.82 | AXL (0.45) | SCDHPGDHSD17B10ALDH1A1POLB | |
| SCHEMBL17837370 | 0.81 | KDM4E (0.48) | HPGDHSD17B10ALDH1A1KDM4ETSHR | |
| SCHEMBL17844419 | 0.80 | CNR2 (0.48) | SCDEGFRTECBTKKDM5A | |
| SCHEMBL18544575 | 0.76 | POLB (0.44) | SRCHPGDHSD17B10ALDH1A1POLB | |
| SCHEMBL15971706 | 0.72 | BTK (0.37) | MAP3K12LMNATRPC6EGFRTEC | |
| SCHEMBL15972152 | 0.72 | HSD11B1 (0.36) | HPGDHSD17B10ALDH1A1POLBBLM | |
| SCHEMBL17844405 | 0.72 | AXL (0.46) | — | |
| SCHEMBL1493459 | 0.71 | ALDH1A1 (0.35) | HPGDHSD17B10ALDH1A1KDM4EGAA | |
| SCHEMBL4706092 | 0.71 | SCD5 (0.34) | SCDHPGDHSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233829-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | Pfizer Inc (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097918-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | PFIZER INC. (US) | 2016-06-23 | — | — | WO | disclosed |