SCHEMBL1784458

SCHEMBL1784458

CCc1cccc(SSc2cccc(CC)c2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.46
DDB1 Q16531 1/20 0.44
CRBN Q96SW2 1/20 0.44
CYP1A2 P05177 2/20 0.41
CYP2A6 P11509 1/20 0.41
MGLL Q99685 2/20 0.41
KIF11 P52732 2/20 0.40
BCL2 P10415 1/20 0.39
RAPGEF4 Q8WZA2 1/20 0.39
HPGD P15428 2/20 0.39
HSD17B10 Q99714 2/20 0.39
CYP2C9 P11712 1/20 0.39
MAPT P10636 2/20 0.39
HTR2C P28335 1/20 0.38
HTR6 P50406 1/20 0.38
TRPA1 O75762 1/20 0.38
SIGMAR1 Q99720 2/20 0.38
IDO1 P14902 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HSP90AA1 P07900 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1786072 0.86 HTR2C (0.52) TP53DDB1CRBNCYP1A2CYP2A6
SCHEMBL5022962 0.84 SIGMAR1 (0.50) TP53DDB1CRBNCYP1A2CYP2A6
SCHEMBL9189880 0.82 HTR2C (0.44) CYP1A2KIF11HPGDHSD17B10CYP2C9
SCHEMBL11806689 0.82 TP53 (0.42) TP53DDB1CRBNCYP1A2CYP2A6
SCHEMBL12251567 0.82 TP53 (0.42) TP53DDB1CRBNCYP1A2CYP2A6
SCHEMBL166894 0.79 TP53 (0.61) TP53CYP1A2CYP2A6MGLLKIF11
SCHEMBL19933041 0.79 DDB1 (0.40) TP53DDB1CRBNCYP1A2CYP2A6
SCHEMBL18773875 0.79 DDB1 (0.40) TP53DDB1CRBNCYP1A2CYP2A6
SCHEMBL12075803 0.77 KIF11 (0.53) TP53DDB1CRBNCYP1A2KIF11
SCHEMBL12300586 0.77 CETP (0.41) TP53DDB1CRBNCYP1A2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5153305-A From diaryl disulfide; mild conditions using organometallic catalyst RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT (JP) 1992-10-06 US claimed
EP-4361200-A1 METHOD FOR MANUFACTURING SULFUR-CONTAINING POLYMER Nippon Shokubai Co., Ltd. (JP) 2024-05-01 EP disclosed
WO-2022270533-A1 METHOD FOR MANUFACTURING SULFUR-CONTAINING POLYMER 株式会社日本触媒 2022-12-29 WO disclosed
EP-2323975-B1 MULTI-RING ANTIOXIDANTS WITH ANTIWEAR PROPERTIES SI GROUP INC (US) 2019-04-24 EP disclosed
US-9796939-B2 Multi-ring antioxidants with antiwear properties SI GROUP, INC. (US) 2017-10-24 US disclosed
US-20140038871-A1 MULTI-RING ANTIOXIDANTS WITH ANTIWEAR PROPERTIES ALBEMARLE CORPORATION (US) 2014-02-06 US disclosed
US-8580718-B2 Multi-ring antioxidants with antiwear properties ALBERMARLE CORPORATION (US) 2013-11-12 US disclosed
US-20110124540-A1 MULTI-RING ANTIOXIDANTS WITH ANTIWEAR PROPERTIES ALBEMARLE CORPORATION (US) 2011-05-26 US disclosed
EP-2323975-A2 MULTI-RING ANTIOXIDANTS WITH ANTIWEAR PROPERTIES Albemarle Corporation (US) 2011-05-25 EP disclosed
WO-2010011523-A2 MULTI-RING ANTIOXIDANTS WITH ANTIWEAR PROPERTIES ALBEMARLE CORPORATION (US) 2010-01-28 WO disclosed
EP-0402481-B1 PRODUCTION OF POLYARYLENE THIOETHER PROD DEV RES INST (JP) 1995-10-25 EP disclosed
US-5290911-A Forming polymers by catalytic oxidative coupling RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT (JP) 1994-03-01 US disclosed
US-5153305-A From diaryl disulfide; mild conditions using organometallic catalyst RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT (JP) 1992-10-06 US disclosed
US-4983720-A Process for preparing a polyarylene thioether IDEMITSU PETROCHEMICAL CO., LTD. (JP) 1991-01-08 US disclosed
EP-0402481-A1 PRODUCTION OF POLYARYLENE THIOETHER RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT (JP) 1990-12-19 EP disclosed
US-4931542-A Process for preparing a polyarylene thioether IDEMITSU PETROCHEMICAL COMPANY, LIMITED (JP) 1990-06-05 US disclosed
EP-0281036-A2 A process for preparing a polyarylene thioether IDEMITSU PETROCHEMICAL CO. LTD. (JP) 1988-09-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110124540-A1 MULTI-RING ANTIOXIDANTS WITH ANTIWEAR PROPERTIES GSR, CBR1, SOD1 TP53 1990/4885DDB1 167/4885CRBN 1722/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.