Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.63 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.63 |
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19639910 | 1.00 | ALDH1A1 (0.66) | ALDH1A1RAB9ATAS1R3TAS1R1PLK1 | |
| SCHEMBL29833379 | 0.89 | ALDH1A1 (0.66) | ALDH1A1RAB9ATAS1R3TAS1R1PLK1 | |
| SCHEMBL14380335 | 0.85 | TAS1R3 (0.67) | ALDH1A1TAS1R3TAS1R1PLK1LMNA | |
| SCHEMBL14115136 | 0.85 | ALDH1A1 (0.70) | ALDH1A1RAB9ALMNAHPGDMEN1 | |
| SCHEMBL24175853 | 0.84 | ALDH1A1 (0.68) | ALDH1A1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL15204487 | 0.84 | ALDH1A1 (0.68) | ALDH1A1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL24807877 | 0.83 | PLK1 (0.57) | ALDH1A1RAB9ATAS1R3TAS1R1PLK1 | |
| SCHEMBL24571817 | 0.82 | ALDH1A1 (0.76) | ALDH1A1RAB9ALMNAHPGDMEN1 | |
| SCHEMBL13767830 | 0.82 | HTT (0.72) | ALDH1A1RAB9ALMNAHPGDMEN1 | |
| SCHEMBL24175872 | 0.82 | HTT (0.72) | ALDH1A1RAB9ALMNAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233836-A1 | INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | Galderma Research & Development (FR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097391-A1 | INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2016-06-23 | — | — | WO | disclosed |