SCHEMBL17845828

SCHEMBL17845828

Cn1c(=O)c2c(nc(Br)n2Cc2ccc(-c3ccccc3)cc2)n(C)c1=O

nearest known ligand 0.73

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.73
SMN1; SMN2 Q16637 2/20 0.73
HIF1A Q16665 1/20 0.73
LMNA P02545 7/20 0.68
TSHR P16473 4/20 0.68
L3MBTL1 Q9Y468 1/20 0.65
RAB9A P51151 1/20 0.62
NPSR1 Q6W5P4 3/20 0.60
MAPT P10636 4/20 0.59
KDM4E B2RXH2 1/20 0.57
HSD17B10 Q99714 2/20 0.57
ALOX15 P16050 1/20 0.57
HTT P42858 3/20 0.56
MAPK1 P28482 2/20 0.56
USP2 O75604 1/20 0.56
HPGD P15428 1/20 0.55
RECQL P46063 1/20 0.55
DPP4 P27487 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16029542 0.86 ALDH1A1 (0.70) ALDH1A1SMN1; SMN2HIF1ALMNATSHR
SCHEMBL31575420 0.85 LMNA (0.60) ALDH1A1SMN1; SMN2HIF1ALMNATSHR
SCHEMBL31575417 0.85 LMNA (0.60) ALDH1A1SMN1; SMN2HIF1ALMNATSHR
SCHEMBL31575394 0.83 ALDH1A1 (0.71) ALDH1A1SMN1; SMN2HIF1ALMNAL3MBTL1
SCHEMBL31575400 0.83 LMNA (0.86) ALDH1A1SMN1; SMN2LMNATSHRRAB9A
SCHEMBL31575392 0.81 SMN1; SMN2 (0.70) ALDH1A1SMN1; SMN2LMNATSHRL3MBTL1
SCHEMBL31575414 0.81 RAB9A (0.78) ALDH1A1SMN1; SMN2HIF1ALMNATSHR
SCHEMBL31575401 0.81 HTT (0.60) ALDH1A1SMN1; SMN2HIF1ALMNATSHR
SCHEMBL17845827 0.81 RECQL (0.67) ALDH1A1SMN1; SMN2LMNATSHRL3MBTL1
SCHEMBL16029357 0.81 SMN1; SMN2 (0.73) ALDH1A1SMN1; SMN2HIF1ALMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120004898-A Compound containing aromatic ring or alicyclic ring and having anti-coronavirus activity and application thereof 中国医学科学院医药生物技术研究所 2025-05-16 CN disclosed
CN-111848712-A End-capped nucleic acid molecules 诺华股份有限公司 2020-10-30 CN disclosed
EP-3233880-A1 END CAPPED NUCLEIC ACID MOLECULES Novartis AG (CH) 2017-10-25 EP disclosed
WO-2016098028-A1 END CAPPED NUCLEIC ACID MOLECULES NOVARTIS AG (CH) 2016-06-23 WO disclosed