Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.35 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8468716 | 0.96 | PNMT (0.49) | PNMTNPC1RAB9AHTR7HTR2B | |
| Tert-Butylamine SCHEMBL27542088 | 0.92 | PNMT (0.44) | PNMTNPC1RAB9AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL4742132 | 0.89 | PNMT (0.41) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL27470292 | 0.85 | PNMT (0.49) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL28044137 | 0.77 | PNMT (0.49) | PNMTNPC1RAB9AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL7060743 | 0.76 | PNMT (0.40) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL7945059 | 0.76 | PNMT (0.40) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL30103334 | 0.76 | PNMT (0.63) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL524602 | 0.76 | PNMT (0.63) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL2877998 | 0.74 | PNMT (0.61) | PNMTNPC1RAB9AHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787545-B2 | Process for the preparation of polyolefin-based graft copolymers comprising a first functionalized short chain branched polyolefin block and one or multiple polymer side chains | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2020-09-29 | — | — | US | disclosed |
| US-20200262983-A1 | PROCESS FOR THE PREPARATION OF POLYOLEFIN-BASED GRAFT COPOLYMERS COMPRISING A FIRST FUNCTIONALIZED SHORT CHAIN BRANCHED POLYOLEFIN BLOCK AND ONE OR MULTIPLE POLYMER SIDE CHAINS | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2020-08-20 | — | — | US | disclosed |
| US-10717826-B2 | Process for the preparation of polyolefin-based graft copolymers comprising a first long chain branched polyolefin block and one or multiple polymer side chains | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2020-07-21 | — | — | US | disclosed |
| EP-3233974-B1 | A PROCESS FOR THE PREPARATION OF A BLOCK COPOLYMER COMPRISING A FIRST POLYOLEFIN BLOCK AND A SECOND POLYMER BLOCK | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2020-02-19 | — | — | EP | disclosed |
| US-10472447-B2 | Process for the preparation of a graft copolymer comprising a polyolefin main chain and one or a multiple polymer side chains and the products obtained therefrom | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2019-11-12 | — | — | US | disclosed |
| US-10465018-B2 | Process for the preparation of a polyolefin having one or multiple end-functionalized branches | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2019-11-05 | — | — | US | disclosed |
| US-10450388-B2 | Process for the preparation of a branched polyolefin | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2019-10-22 | — | — | US | disclosed |
| EP-3233976-B1 | A PROCESS FOR THE PREPARATION OF A BLOCK COPOLYMER COMPRISING A FIRST POLYOLEFIN BLOCK AND A SECOND POLYMER BLOCK | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2019-10-16 | — | — | EP | disclosed |
| EP-3233975-B1 | A PROCESS FOR THE PREPARATION OF A GRAFT COPOLYMER COMPRISING A POLYOLEFIN MAIN CHAIN AND ONE OR A MULTIPLE POLYMER SIDE CHAINS | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2019-08-14 | — | — | EP | disclosed |
| EP-3233977-B1 | A PROCESS FOR THE PREPARATION OF A GRAFT COPOLYMER COMPRISING A POLYOLEFIN MAIN CHAIN AND ONE OR A MULTIPLE POLYMER SIDE CHAINS | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017097569-A1 | PROCESS FOR THE PREPARATION OF POLYOLEFIN-BASED GRAFT COPOLYMERS COMPRISING A FIRST FUNCTIONALIZED SHORT CHAIN BRANCHED POLYOLEFIN BLOCK AND ONE OR MULTIPLE POLYMER SIDE CHAINS | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-06-15 | — | — | WO | disclosed |
| WO-2017097568-A1 | PROCESS FOR THE PREPARATION OF POLYOLEFIN-BASED GRAFT COPOLYMERS COMPRISING A FIRST LONG CHAIN BRANCHED POLYOLEFIN BLOCK AND ONE OR MULTIPLE POLYMER SIDE CHAINS | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-06-15 | — | — | WO | disclosed |
| WO-2017097571-A1 | PROCESS FOR THE PREPARATION OF POLYOLEFIN-BASED GRAFT COPOLYMERS COMPRISING A FIRST FUNCTIONALIZED SHORT CHAIN BRANCHED POLYOLEFIN BLOCK AND ONE OR MULTIPLE POLYMER SIDE CHAINS | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-06-15 | — | — | WO | disclosed |
| WO-2017097570-A1 | PROCESS FOR THE PREPARATION OF POLYOLEFIN-BASED GRAFT COPOLYMERS COMPRISING A FIRST LONG CHAIN BRANCHED POLYOLEFIN BLOCK AND ONE OR MULTIPLE POLYMER SIDE CHAINS | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-06-15 | — | — | WO | disclosed |
| WO-2016102694-A1 | PROCESS FOR THE PREPARATION OF A POLYOLEFIN HAVING ONE OR MULTIPLE END-FUNCTIONALIZED BRANCHES | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016102690-A1 | PROCESS FOR THE PREPARATION OF A BRANCHED POLYOLEFIN | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016097204-A1 | A PROCESS FOR THE PREPARATION OF A GRAFT COPOLYMER COMPRISING A POLYOLEFIN MAIN CHAIN AND ONE OR A MULTIPLE POLYMER SIDE CHAINS AND THE PRODUCTS OBTAINED THEREFROM | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016097203-A1 | A PROCESS FOR THE PREPARATION OF A BLOCK COPOLYMER COMPRISING A FIRST POLYOLEFIN BLOCK AND A SECOND POLYMER BLOCK AS WELL AS THE PRODUCTS OBTAINED THEREFROM | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016097208-A1 | A PROCESS FOR THE PREPARATION OF A BLOCK COPOLYMER COMPRISING A FIRST POLYOLEFIN BLOCK AND A SECOND POLYMER BLOCK AND THE PRODUCTS OBTAINED THEREFROM | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016097207-A1 | A PROCESS FOR THE PREPARATION OF A GRAFT COPOLYMER COMPRISING A POLYOLEFIN MAIN CHAIN AND ONE OR A MULTIPLE POLYMER SIDE CHAINS AND THE PRODUCTS OBTAINED THEREFROM | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2016-06-23 | — | — | WO | disclosed |