Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL28686046 | 0.90 | TSHR (0.56) | DAOTSHRNAPRTALDH1A1RAB9A | |
| Benzoic Acid SCHEMBL571245 | 0.90 | TSHR (0.56) | DAOTSHRNAPRTALDH1A1RAB9A | |
| Benzoic Acid SCHEMBL561248 | 0.85 | DAO (0.47) | DAOTSHRNAPRTALDH1A1RAB9A | |
| Benzoic Acid SCHEMBL569215 | 0.83 | TSHR (0.52) | DAOTSHRNAPRTALDH1A1RAB9A | |
| Benzoyl Formic Acid SCHEMBL16044060 | 0.82 | CES2 (0.50) | DAOTSHRNAPRTALDH1A1CES2 | |
| Benzoic Acid SCHEMBL29415230 | 0.79 | DAO (0.44) | DAOTSHRNAPRTALDH1A1RAB9A | |
| Benzoic Acid SCHEMBL28797334 | 0.79 | DAO (0.44) | DAOTSHRNAPRTALDH1A1RAB9A | |
| Benzoic Acid SCHEMBL1081754 | 0.79 | DAO (0.47) | DAOTSHRNAPRTALDH1A1RAB9A | |
| Benzoic Acid SCHEMBL27925082 | 0.79 | DAO (0.47) | DAOTSHRNAPRTALDH1A1RAB9A | |
| Benzoic Acid SCHEMBL17594839 | 0.79 | TSHR (0.61) | DAOTSHRNAPRTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472293-B1 | SOLID CATALYST COMPONENT FOR POLYMERIZATION OF OLEFINS, CATALYST COMPRISING THE SAME AND USE THEREOF | CHINA PETROLEUM & CHEM CORP (CN) | 2017-04-26 | — | — | EP | claimed |
| US-7388061-B2 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2008-06-17 | — | — | US | claimed |
| US-20050239636-A1 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-10-27 | — | — | US | claimed |
| EP-3805277-A1 | PROCATALYST COMPOSITIONS USEFUL FOR LOW COMONOMER INCORPORATION AND PROCESS FOR PREPARING THE SAME | Dow Global Technologies LLC (US) | 2021-04-14 | — | — | EP | disclosed |
| EP-3478730-B1 | PROCESS FOR PREPARING A PROCATALYST COMPOSITIONS USEFUL FOR LOW COMONOMER INCORPORATION | DOW GLOBAL TECHNOLOGIES LLC (US) | 2021-03-10 | — | — | EP | disclosed |
| US-20190322774-A1 | PROCATALYST COMPOSITIONS USEFUL FOR LOW COMONOMER INCORPORATION AND PROCESS FOR PREPARING THE SAME | DOW GLOBAL TECHNOLOGIES LLC (US) | 2019-10-24 | — | — | US | disclosed |
| EP-3486263-A2 | SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE | W.R. Grace & CO. - CONN. (US) | 2019-05-22 | — | — | EP | disclosed |
| EP-3478730-A1 | PROCATALYST COMPOSITIONS USEFUL FOR LOW COMONOMER INCORPORATION AND PROCESS FOR PREPARING THE SAME | Dow Global Technologies LLC (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-2185600-B1 | SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE | GRACE W R & CO (US) | 2018-10-31 | — | — | EP | disclosed |
| WO-2018005789-A1 | PROCATALYST COMPOSITIONS USEFUL FOR LOW COMONOMER INCORPORATION AND PROCESS FOR PREPARING THE SAME | DOW GLOBAL TECHNOLOGIES LLC (US) | 2018-01-04 | — | — | WO | disclosed |
| US-9796796-B2 | Self-limiting catalyst composition with No silane | W. R. GRACE & CO.-CONN. (US) | 2017-10-24 | — | — | US | disclosed |
| EP-1472293-B1 | SOLID CATALYST COMPONENT FOR POLYMERIZATION OF OLEFINS, CATALYST COMPRISING THE SAME AND USE THEREOF | CHINA PETROLEUM & CHEM CORP (CN) | 2017-04-26 | — | — | EP | disclosed |
| EP-1666505-B1 | CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF | CHINA PETROLEUM & CHEMICAL (CN) | 2016-03-23 | — | — | EP | disclosed |
| US-20130109789-A1 | OLEFIN POLYMERIZATION CATALYST, PROCESS FOR PRODUCING OLEFIN POLYMER, POLYPROPYLENE RESIN COMPOSITION AND ARTICLE COMPRISING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-05-02 | — | — | US | disclosed |
| US-20110124491-A1 | Self-Limiting Catalyst Composition with No Silane | W. R. GRACE & CO.-CONN. | 2011-05-26 | — | — | US | disclosed |
| US-7388061-B2 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2008-06-17 | — | — | US | disclosed |
| US-7332455-B2 | Catalyst component and catalyst for olefin polymerization as well as use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2008-02-19 | — | — | US | disclosed |
| EP-1666505-A1 | CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF | China Petroleum & Chemical Corporation (CN) | 2006-06-07 | — | — | EP | disclosed |
| US-20050239636-A1 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-10-27 | — | — | US | disclosed |
| US-20050119427-A1 | Catalyst component and catalyst for olefin polymerization as well as use thereof | BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-06-02 | — | — | US | disclosed |