Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL28686046 | 1.00 | TSHR (0.56) | TSHRDAONAPRTCES1SRD5A2 | |
| Benzoic Acid SCHEMBL569215 | 0.92 | TSHR (0.52) | TSHRDAONAPRTCES1SRD5A2 | |
| Benzoyl Formic Acid SCHEMBL16044060 | 0.91 | CES2 (0.50) | TSHRDAONAPRTCES1SRD5A2 | |
| Benzoic Acid SCHEMBL1784645 | 0.90 | DAO (0.45) | TSHRDAONAPRTCES1SRD5A2 | |
| Benzoic Acid SCHEMBL29415230 | 0.88 | DAO (0.44) | TSHRDAONAPRTCES1SRD5A2 | |
| Benzoic Acid SCHEMBL561248 | 0.88 | DAO (0.47) | TSHRDAONAPRTCES1SRD5A2 | |
| Benzoic Acid SCHEMBL27925082 | 0.88 | DAO (0.47) | TSHRDAONAPRTCES1SRD5A2 | |
| Benzoic Acid SCHEMBL16044723 | 0.87 | DAO (0.42) | TSHRDAONAPRTCES1SRD5A2 | |
| Benzoic Acid SCHEMBL16044142 | 0.87 | TSHR (0.48) | TSHRDAONAPRTCES1SRD5A2 | |
| Benzoic Acid SCHEMBL28702834 | 0.86 | TSHR (0.54) | TSHRDAONAPRTCES1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 279 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118290623-A | Polypropylene and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-07-05 | — | — | CN | claimed |
| CN-118290624-A | Polypropylene and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-07-05 | — | — | CN | claimed |
| CN-118290625-A | Polypropylene and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-07-05 | — | — | CN | claimed |
| CN-117756970-A | Catalyst for butene-1 polymerization and application thereof | 中国石油化工股份有限公司 | 2024-03-26 | — | — | CN | claimed |
| CN-117430732-A | Catalyst component for propylene polymerization, preparation method thereof, catalyst and application | 中国石油化工股份有限公司 | 2024-01-23 | — | — | CN | claimed |
| CN-114478846-B | Carrier of catalyst with olefin polymerization catalyzing function, preparation method and application thereof, olefin polymerization catalyst and application thereof | 中国石油化工股份有限公司 | 2023-09-08 | — | — | CN | claimed |
| CN-110938161-B | Catalyst system for olefin polymerization and prepolymerized catalyst composition and use thereof | 中国石油化工股份有限公司 | 2022-05-24 | — | — | CN | claimed |
| CN-114478846-A | Carrier of catalyst with function of catalyzing olefin polymerization, preparation method and application of carrier, olefin polymerization catalyst and application of olefin polymerization catalyst | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-114426599-A | Catalyst component for preparing polyolefin, preparation method thereof, olefin polymerization catalyst and application thereof | 中国石油化工股份有限公司 | 2022-05-03 | — | — | CN | claimed |
| CN-113754801-A | Solid catalyst for preparing olefin polymer and solid catalyst system | 中国石油化工股份有限公司 | 2021-12-07 | — | — | CN | claimed |
| US-9068026-B2 | Magnesium halide adducts, catalyst components and catalysts comprising the same, and preparation processes thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2015-06-30 | — | — | US | claimed |
| CN-104558282-A | Catalyst component used for olefin polymerization and preparation method thereof as well as catalyst used for olefin polymerization and application | CHINA PETROLEUM & CHEMICAL | 2015-04-29 | — | — | CN | claimed |
| CN-104558293-A | Catalyst component for olefin polymerization and catalyst | CHINA PETROLEUM & CHEMICAL | 2015-04-29 | — | — | CN | claimed |
| CN-104558284-A | Catalyst component used for olefin polymerization and preparation method thereof as well as catalyst used for olefin polymerization and application | CHINA PETROLEUM & CHEMICAL | 2015-04-29 | — | — | CN | claimed |
| CN-103665205-A | Catalyst component applied to olefin polymerization, preparation method thereof, catalyst for olefin polymerization and application of catalyst | CHINA PETROLEUM & CHEMICAL | 2014-03-26 | — | — | CN | claimed |
| US-20120302708-A1 | MAGNESIUM HALIDE ADDUCTS, CATALYST COMPONENTS AND CATALYSTS COMPRISING THE SAME, AND PREPARATION PROCESSES THEREOF | BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2012-11-29 | — | — | US | claimed |
| US-7388061-B2 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2008-06-17 | — | — | US | claimed |
| US-20050239636-A1 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-10-27 | — | — | US | claimed |
| US-20050096389-A1 | Polyol ester compounds useful in preparation of a catalyst for olefins polymerization, process for preparing the same and use thereof | CHINA PETROLEUM & CHEMICAL (CN) | 2005-05-05 | — | — | US | claimed |
| CN-1580034-A | Glycol ester compound for preparing catalyst for olefinic polymerization | CHINA PETROCHEMICAL CORP (CN) | 2005-02-16 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096389-A1 | Polyol ester compounds useful in preparation of a catalyst for olefins polymerization, process for preparing the same and use thereof | CBR3, CBR1, OXER1 | TSHR 921/4885DAO 1971/4885NAPRT 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.