Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734875 | 0.98 | KMT2A (0.45) | KMT2AMEN1RCE1RAB9AALDH1A1 | |
| Bromide SCHEMBL144907 | 0.96 | KMT2A (0.47) | KMT2AMEN1RCE1RAB9AALDH1A1 | |
| Sulfuric Acid SCHEMBL141469 | 0.87 | KMT2A (0.38) | KMT2AMEN1RCE1RAB9AALDH1A1 | |
| Sulfuric Acid SCHEMBL141470 | 0.87 | KMT2A (0.38) | KMT2AMEN1RCE1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9250120 | 0.83 | HTT (0.42) | KMT2AMEN1RCE1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL19031270 | 0.82 | ALDH1A1 (0.47) | KMT2AMEN1RCE1RAB9AALDH1A1 | |
| SCHEMBL19037386 | 0.82 | KMT2A (0.50) | KMT2AMEN1RCE1RAB9ASMN1; SMN2 | |
| SCHEMBL14621784 | 0.82 | KMT2A (0.50) | KMT2AMEN1RCE1RAB9AALDH1A1 | |
| SCHEMBL11925329 | 0.82 | MEN1 (0.64) | KMT2AMEN1RCE1RAB9AALDH1A1 | |
| SCHEMBL290669 | 0.82 | KMT2A (0.42) | KMT2AMEN1RCE1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233801-B1 | USE OF PARTICULAR PYRIDINIUM SALTS FOR THE TREATMENT OF KERATIN SUBSTANCES, COMPOSITIONS AND IMPLEMENTATION METHODS | OREAL (FR) | 2022-06-08 | — | — | EP | claimed |
| US-20170340543-A1 | USE OF PARTICULAR PYRIDINIUM SALTS FOR THE TREATMENT OF KERATIN SUBSTANCES, COMPOSITIONS AND IMPLEMENTATION METHODS | L'OREAL (FR) | 2017-11-30 | — | — | US | claimed |
| EP-3233801-A1 | USE OF PARTICULAR PYRIDINIUM SALTS FOR THE TREATMENT OF KERATIN SUBSTANCES, COMPOSITIONS AND IMPLEMENTATION METHODS | L'OREAL (FR) | 2017-10-25 | — | — | EP | claimed |
| WO-2016097413-A1 | USE OF PARTICULAR PYRIDINIUM SALTS FOR THE TREATMENT OF KERATIN SUBSTANCES, COMPOSITIONS AND IMPLEMENTATION METHODS | L'OREAL (FR) | 2016-06-23 | — | — | WO | claimed |
| EP-3233801-B1 | USE OF PARTICULAR PYRIDINIUM SALTS FOR THE TREATMENT OF KERATIN SUBSTANCES, COMPOSITIONS AND IMPLEMENTATION METHODS | OREAL (FR) | 2022-06-08 | — | — | EP | disclosed |
| CN-106999394-B | Use, composition and implementation method of specific pyridinium salt for treating keratin materials | 欧莱雅 | 2021-09-24 | — | — | CN | disclosed |
| US-10765615-B2 | Use of particular pyridinium salts for the treatment of keratin substances, compositions and implementation methods | L'OREAL (FR) | 2020-09-08 | — | — | US | disclosed |
| US-20170340543-A1 | USE OF PARTICULAR PYRIDINIUM SALTS FOR THE TREATMENT OF KERATIN SUBSTANCES, COMPOSITIONS AND IMPLEMENTATION METHODS | L'OREAL (FR) | 2017-11-30 | — | — | US | disclosed |
| EP-3233801-A1 | USE OF PARTICULAR PYRIDINIUM SALTS FOR THE TREATMENT OF KERATIN SUBSTANCES, COMPOSITIONS AND IMPLEMENTATION METHODS | L'OREAL (FR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097413-A1 | USE OF PARTICULAR PYRIDINIUM SALTS FOR THE TREATMENT OF KERATIN SUBSTANCES, COMPOSITIONS AND IMPLEMENTATION METHODS | L'OREAL (FR) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340543-A1 | USE OF PARTICULAR PYRIDINIUM SALTS FOR THE TREATMENT OF KERATIN SUBSTANCES, COMPOSITIONS AND IMPLEMENTATION METHODS | KRT18, PLPBP, PNPO | KMT2A 1799/4885MEN1 2850/4885RCE1 4160/4885 |
| US-10765615-B2 | Use of particular pyridinium salts for the treatment of keratin substances, compositions and implementation methods | KRT18, PLPBP, PNPO | KMT2A 1799/4885MEN1 2850/4885RCE1 4160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.