Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14453570 | 0.86 | SMN1; SMN2 (0.66) | SMN1; SMN2MEN1KMT2ADRD2KDM4E | |
| SCHEMBL19145145 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2MEN1KMT2ADRD2HTR1A | |
| SCHEMBL17848636 | 0.82 | HTR7 (0.61) | DRD2HTR1AHTR7HTR2A | |
| SCHEMBL17848328 | 0.79 | LTA4H (0.49) | DRD2HTR1AHTR7HTR2A | |
| SCHEMBL17320456 | 0.76 | NR1H2 (0.49) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL30023518 | 0.75 | HRH1 (0.54) | MEN1KMT2ADRD2KDM4EALDH1A1 | |
| SCHEMBL28870036 | 0.75 | HRH1 (0.54) | MEN1KMT2ADRD2KDM4EALDH1A1 | |
| SCHEMBL14570558 | 0.74 | HRH3 (0.66) | MEN1KMT2AALDH1A1 | |
| SCHEMBL16255800 | 0.74 | S1PR1 (0.46) | SYK | |
| SCHEMBL12309472 | 0.74 | MCHR1 (0.52) | SMN1; SMN2MEN1KMT2AHTR1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |