Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 9/20 | 0.61 |
| ▸ | HTR1A | P08908 | 7/20 | 0.61 |
| ▸ | DRD2 | P14416 | 11/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848618 | 0.86 | HTR1A (0.61) | HTR7HTR1ADRD2LTA4HPTGS2 | |
| SCHEMBL20224891 | 0.84 | HTR7 (0.59) | HTR7HTR1ADRD2LTA4HPTGS2 | |
| SCHEMBL17848523 | 0.83 | HTR1A (0.58) | HTR7HTR1ADRD2LTA4HPTGS2 | |
| SCHEMBL17848348 | 0.83 | LTA4H (0.73) | HTR7HTR1ADRD2LTA4HPTGS2 | |
| SCHEMBL14970707 | 0.83 | LTA4H (0.73) | HTR7HTR1ADRD2LTA4HPTGS2 | |
| SCHEMBL17848433 | 0.82 | SMN1; SMN2 (0.49) | HTR7HTR1ADRD2HTR2A | |
| SCHEMBL17848363 | 0.82 | HTR7 (0.60) | HTR7HTR1ADRD2LTA4HPTGS2 | |
| Hydrochloric Acid SCHEMBL14969001 | 0.82 | LTA4H (0.71) | HTR7HTR1ADRD2LTA4HPTGS2 | |
| SCHEMBL17848328 | 0.81 | LTA4H (0.49) | HTR7HTR1ADRD2LTA4HPTGS2 | |
| SCHEMBL7601343 | 0.81 | HTR2C (0.60) | HTR7HTR1ADRD2LTA4HPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |