Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848492 | 0.89 | DRD2 (0.72) | DRD2MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL17848491 | 0.87 | DRD2 (0.86) | DRD2MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL17848429 | 0.86 | DRD2 (0.77) | DRD2 | |
| SCHEMBL17848775 | 0.86 | DRD2 (0.80) | DRD2 | |
| SCHEMBL17848317 | 0.85 | DRD2 (0.72) | DRD2CYP1A2CYP2D6CYP2C19L3MBTL1 | |
| SCHEMBL17848770 | 0.85 | DRD2 (0.67) | DRD2ALDH1A1 | |
| SCHEMBL20224807 | 0.81 | DRD2 (0.85) | DRD2 | |
| SCHEMBL17848484 | 0.80 | DRD2 (0.87) | DRD2 | |
| SCHEMBL17848496 | 0.80 | DRD2 (0.81) | DRD2CYP1A2CYP2D6CYP2C19L3MBTL1 | |
| SCHEMBL17848392 | 0.79 | DRD2 (0.78) | DRD2CYP1A2CYP2D6CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |