Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848775 | 0.92 | DRD2 (0.80) | DRD2TSHRLTA4H | |
| SCHEMBL17848380 | 0.87 | DRD2 (0.80) | DRD2LTA4HHTR1ADRD1DRD5 | |
| SCHEMBL17848502 | 0.85 | DRD2 (0.76) | DRD2TSHR | |
| SCHEMBL17848766 | 0.85 | DRD2 (0.65) | DRD2ALDH1A1 | |
| SCHEMBL17848429 | 0.85 | DRD2 (0.77) | DRD2TSHR | |
| SCHEMBL17848317 | 0.84 | DRD2 (0.72) | DRD2TSHRHTR1AHTR7ALDH1A1 | |
| SCHEMBL17848339 | 0.82 | DRD2 (0.80) | DRD2TSHRLTA4HHTR1AHTR7 | |
| SCHEMBL17848595 | 0.81 | DRD2 (0.78) | DRD2LTA4HHTR1AHTR2AHRH1 | |
| SCHEMBL17848571 | 0.81 | DRD2 (1.00) | DRD2LTA4HALDH1A1 | |
| SCHEMBL17848350 | 0.81 | DRD2 (0.77) | DRD2HTR1ADRD1DRD5SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |