Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30063990 | 0.88 | ECE1 (0.42) | SCN9AECE1GBA2PTGDR2DPP4 | |
| SCHEMBL932669 | 0.81 | RIPK1 (0.46) | RIPK1HCRTR2NTRK1JAK2 | |
| SCHEMBL17821025 | 0.80 | NTRK1 (0.44) | SCN9ARIPK1NTRK1 | |
| SCHEMBL17820744 | 0.80 | NTRK1 (0.44) | SCN9ARIPK1NTRK1 | |
| SCHEMBL17820748 | 0.80 | NTRK1 (0.44) | SCN9ARIPK1NTRK1 | |
| SCHEMBL23083856 | 0.80 | NTRK1 (0.44) | SCN9ARIPK1NTRK1 | |
| SCHEMBL21313058 | 0.77 | SCN9A (0.44) | SCN9ARIPK1DPP4FAPDPP8 | |
| SCHEMBL21313092 | 0.77 | SCN9A (0.44) | SCN9ARIPK1DPP4FAPDPP8 | |
| SCHEMBL29891866 | 0.76 | HTR2A (0.39) | HTR2A | |
| SCHEMBL932557 | 0.75 | NTRK1 (0.44) | RIPK1PTGDR2LMNARECQLHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233863-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG Pharmaceutical Co., Ltd. (KR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097869-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG PHARMACEUTICAL CO., LTD. (KR) | 2016-06-23 | — | — | WO | disclosed |