Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.44 |
| ▸ | JAK2 | O60674 | 6/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2692795 | 0.80 | NTRK1 (0.46) | NTRK1JAK2 | |
| SCHEMBL2692794 | 0.80 | NTRK1 (0.46) | NTRK1JAK2 | |
| SCHEMBL28688005 | 0.79 | NTRK1 (0.48) | NTRK1JAK2MEN1KMT2AATM | |
| SCHEMBL28688004 | 0.79 | NTRK1 (0.48) | NTRK1JAK2MEN1KMT2AATM | |
| SCHEMBL932669 | 0.78 | RIPK1 (0.46) | NTRK1JAK2HCRTR2RIPK1 | |
| SCHEMBL17848871 | 0.75 | SCN9A (0.42) | NTRK1JAK2HTR2AKMT2ALMNA | |
| SCHEMBL30142170 | 0.72 | LMNA (0.38) | NTRK1HTR2AMEN1KMT2ALMNA | |
| SCHEMBL18812548 | 0.71 | NTRK1 (0.43) | NTRK1JAK2MEN1KMT2AATM | |
| SCHEMBL14158149 | 0.69 | LMNA (0.39) | LMNAPOLBATMALDH1A1 | |
| SCHEMBL29891866 | 0.69 | HTR2A (0.39) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |